934560-45-9Relevant academic research and scientific papers
Implications for selectivity of 3,4-diarylquinolinones as p38αMAP kinase inhibitors
Peifer, Christian,Urich, Robert,Schattel, Verena,Abadleh, Mohammed,Roettig, Marc,Kohlbacher, Oliver,Laufer, Stefan
, p. 1431 - 1435 (2008/12/21)
In this study we report on the specificity profiling of the MAP kinase inhibitors 1, 2, and 3 in a panel of 78 protein kinases including the MAPK isoforms p38(α,β,γ,δ), JNK1/2/3, and ERK1/2/8 showing 3-(4-fluorophenyl)-4-pyridin-4-ylquinolin-2(1H)-one (1)
From five- to six-membered rings: 3,4-Diarylquinolinone as lead for novel p38MAP kinase inhibitors
Peifer, Christian,Kinkel, Katrin,Abadleh, Mohammed,Schollmeyer, Dieter,Laufer, Stefan
, p. 1213 - 1221 (2007/10/03)
In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38αMAPK IC50 of 1.8 μM. By keeping the common vicinal pyridine/4-F-phenyl
