127047-77-2

Usage

InChI:InChI=1/C9H15IO4/c1-7(11)13-5-9(3-4-10)6-14-8(2)12/h9H,3-6H2,1-2H3

Upstream product

• 78386-41-1 3-acetoxymethyl tetrahydrofuran 
• 75-36-5 acetyl chloride 
• 124391-75-9 3-tetrahydrofuranmethanol 
• 131266-10-9 2-acetoxymethyl-4-benzyloxybutyl acetate 
• 77661-80-4 2-(2-(benzyloxy)ethyl)propane-1,3-diol 
• 126589-88-6 1,3-diacetoxy-2-(2-hydroxyethyl)propane 
• 128139-38-8 Acetic acid 2-acetoxymethyl-4-methanesulfonyloxy-butyl ester 

Downstream Products

• 131266-20-1 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-bromopurine 
• 131266-21-2 7-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-bromopurine 
• 97845-60-8 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine 
• 97845-61-9 7-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine 
• 131266-15-4 7-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 
• 104227-87-4 9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 
• 128139-27-5 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-iodopurine 
• 131266-22-3 7-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-iodopurine 

Relevant academic research and scientific papers

Regioselective cleavage of tetrahydrofurans bearing proximate functional groups with acid iodides

Tetrahydrofurans functionalized at the C2 or C3 position (alcohols, esters, amine, ether, acetal) are cleaved with RCOCl/NaI (R = Me, tBu) in acetonitrile to give regioselectively trifunctionalized derivatives. In all cases the cleavage occurs mainly or exclusively at the C-O bond the most remote from the functional group.

A PROCESS FOR THE PREPARATION OF 2-ACETOXYMETHYL-4 HALO-BUT-1-YL ACETATES

A process for the preparation of 2- acetoxymethyl-4-halo-but-l-yl acetates (I) in which X is chlorine or bromine, which are useful intermediates for the preparation of antiviral medicaments such as Penciclovir and Famciclovir, comprising the opening of 3-hydroxymethyl-tetrahydrofuran (V) in the presence of an acylating agent and a Lewis acid selected from magnesium bromide and samarium triiodide.