1270943-00-4Relevant academic research and scientific papers
Synthesis and Modular Reactivity of Pyrazole 5-Trifluoroborates: Intermediates for the Preparation of Fully Functionalized Pyrazoles
Fricero, Prisca,Bialy, Laurent,Brown, Andrew W.,Czechtizky, Werngard,Méndez, María,Harrity, Joseph P. A.
, p. 1688 - 1696 (2017/02/10)
The regioselective condensation of hydrazines and ynone trifluoroborates provides access to a range of pyrazole 5-trifluoroborates. The stability of the borate unit allows chemoselective halogenation of the heteroaromatic ring, thereby delivering pyrazole scaffolds that allow orthogonal functionalization at C5 and C4. The modular reactivity of these intermediates is exemplified by cross-coupling reactions, enabling regiocontrolled synthesis of fully functionalized pyrazole derivatives.
Regioselective Synthesis of 4-Nitro- or 4-Chloro-Tetrasubstituted Pyrazoles from Hydrazones and β-Halo-β-nitrostyrenes
Deng, Xiaohu,Liang, Jimmy T.,Mani, Neelakandha S.
, p. 410 - 417 (2015/10/05)
We report an acid-catalyzed cycloaddition reaction of hydrazones with β-bromo- or β-chloro-β-nitrostyrenes for the regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles. Arising from a common 4-halo-4-nitropyrazolidine intermediate,
Regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles from hydrazones and β-halo-β-nitrostyrenes
Deng, Xiaohu,Liang, Jimmy T.,Mani, Neelakandha S.
, p. 410 - 417 (2014/01/23)
We report an acid-catalyzed cycloaddition reaction of hydrazones with β-bromo- or β-chloro-β-nitrostyrenes for the regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles. Arising from a common 4-halo-4-nitropyrazolidine intermediate,
Rapid one-pot, four-step synthesis of highly fluorescent 1,3,4,5-tetrasubstituted pyrazoles
Willy, Benjamin,Mueller, Thomas J.J.
supporting information; experimental part, p. 2082 - 2085 (2011/06/24)
1,3,4,5-Tetrasubstituted pyrazoles can be rapidly and efficiently synthesized in a one-pot, four-step sequence consisting of Sonogashira coupling, addition-cyclocondensation, bromination, and Suzuki coupling. The second and the last step are microwave-ass
