25007-79-8

Usage

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.

InChI:InChI=1/C8H8N6/c9-7-12-6(13-8(10)14-7)5-3-1-2-4-11-5/h1-4H,(H4,9,10,12,13,14)

Upstream product

• 100-70-9 2-Cyanopyridine 
• 127099-85-8 N-Cyanoguanidine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 127099-85-8 dicyandiamide 
• 109-86-4 2-methoxy-ethanol 

Relevant academic research and scientific papers

Cis-trans isomerism modulates the magnetic relaxation of dysprosium single-molecule magnets

Geometry and magnetic relaxation modulations in a series of mononuclear dysprosium complexes, [DyLz2(o-vanilin)2]·X·solvent (Lz = 6-pyridin-2-yl-[1,3,5]triazine-2,4-diamine; X = Br- (1), NO3- (2), CF3SO3- (3)), were realized by changing the nature of the counter-Anion. The DyIII ions in all complexes are eight-coordinate and in approximate D4d symmetry environments. The magnetic relaxation and anisotropy of these complexes were systematically investigated, both experimentally and from ab initio calculations. All complexes exhibit excellent single-molecule magnetic behavior. Remarkably, magneto-structural studies show that the rotation of the coordinating plane of the square-Antiprismatic environment in complex 2 induces a magnetic relaxation path through higher excited states, yielding a high anisotropy barrier of 615 K (696 K for a diluted sample). Additionally, obvious opening of the hysteresis loop is observed up to 7 K, which is the highest blocking temperature ever reported for dysprosium single-molecule magnets.

Synthesis and crystal structure of two polydimensional molecular architectures from cobalt(II), copper(II) complexes of 2,4-diamino-6-pyridyl-1, 3,5-triazine

Two new Co(II) and Cu(II) complexes of 2,4-diamino-6-pyridyl-1,3,5-triazine (ptzda) have been synthesized and structurally characterized. Crystal structure studies reveal that Co atom is six-coordinated by four nitrogen atoms from four dicyanamide anions and the other two nitrogen atoms from 2,4-diamino-6-pyridyl- 1,3,5-triazine and each cobalt atom are connected by two [N(CN) 2]- anions to form an infinite double-stranded bridge fashion to give 2D ladder-like motifs. Whereas, Cu atom is five-coordinated by two nitrogen atoms from two dicyanamide anions and the other two nitrogen atoms from 2,4-diamino-6-pyridyl-1,3,5-triazine and each copper atom is connected by one methanol to form an infinite double-stranded bridge fashion to give 1D ladder-like motifs.

Water-soluble DNA minor groove binders as potential chemotherapeutic agents: Synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions

Two new water-soluble copper(ii)-dipeptide complexes: [Cu(glygly)(PyTA)] ClO4·1.5H2O (1) and [Cu(glygly)(PzTA)]ClO 4·1.5H2O (2) (glygly = glycylglycine anion, PyTA = 2,4-diamino-6-(2′-pyridyl)-1,3,5-triazine and PzTA = 2,4-diamino-6- (2′-pyrazino)-1,3,5-triazine), utilizing two interrelated DNA base-like ligands (PyTA and PzTA), have been synthesized and characterized. The structure elucidation for 1 performed by single crystal X-ray diffraction showed a one dimensional chain conformation in which the central copper ions arrange in a five-coordinate distorted square-pyramidal geometry. Spectroscopic titration, viscosity and electrophoresis measurements revealed that the complexes bound to DNA via an outside groove binding mode, and cleaved pBR322 DNA efficiently in the presence of ascorbate, probably via an oxidative mechanism with the involvement of OH and O2-. Notably, the complexes exhibited considerable in vitro cytotoxicity against four human carcinoma cell lines (HepG2, HeLa, A549 and U87) with IC50 values ranging from 41.68 to 159.17 μM, in addition to their excellent SOD mimics (IC50 ～ 0.091 and 0.114 μM). Besides, multispectroscopic evidence suggested their HSA-binding at the cavity containing Trp-214 in subdomain IIA with moderate affinity, mainly via hydrophobic interaction. Further, the molecular docking technique utilized for ascertaining the mechanism and mode of action towards DNA and HSA theoretically verified the experimental results.

Synthesis of O2-and N3-(2-phosphonomethoxy)ethyl derivatives of 6-phenyl- and 6-pyridinyl-5-azacytosine

A series of hydrolytically stable O2- and N3-(2- phosphonomethoxy)- ethyl (PME) derivatives of 6-phenyl, pyridin-2, -3 and -4-yl-5-azacytosines was prepared by their alkylation with diisopropyl (2-chloroethoxy)methylphosphonate followed by the deprotection. No antitumor or antiviral activity was found except for 6-(pyridin-4-yl)-1,3,5-triazine-2,4- diamine (13d) which exhibited slight activity against feline herpesvirus in CrFK cell cultures with IC50 = 6.7 μg/mL.

INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS

Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject.

Direct conversion of aldehydes to amides, tetrazoles, and triazines in aqueous media by one-pot tandem reactions

A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to high yields. The one-pot tandem reactions were conducted in water media, and the products were obtained simply by extraction or filtration.