25007-79-8Relevant articles and documents
Cis-trans isomerism modulates the magnetic relaxation of dysprosium single-molecule magnets
Wu, Jianfeng,Jung, Julie,Zhang, Peng,Zhang, Haixia,Tang, Jinkui,Le Guennic, Boris
, p. 3632 - 3639 (2016)
Geometry and magnetic relaxation modulations in a series of mononuclear dysprosium complexes, [DyLz2(o-vanilin)2]·X·solvent (Lz = 6-pyridin-2-yl-[1,3,5]triazine-2,4-diamine; X = Br- (1), NO3- (2), CF3SO3- (3)), were realized by changing the nature of the counter-Anion. The DyIII ions in all complexes are eight-coordinate and in approximate D4d symmetry environments. The magnetic relaxation and anisotropy of these complexes were systematically investigated, both experimentally and from ab initio calculations. All complexes exhibit excellent single-molecule magnetic behavior. Remarkably, magneto-structural studies show that the rotation of the coordinating plane of the square-Antiprismatic environment in complex 2 induces a magnetic relaxation path through higher excited states, yielding a high anisotropy barrier of 615 K (696 K for a diluted sample). Additionally, obvious opening of the hysteresis loop is observed up to 7 K, which is the highest blocking temperature ever reported for dysprosium single-molecule magnets.
Water-soluble DNA minor groove binders as potential chemotherapeutic agents: Synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions
Fu, Xia-Bing,Liu, Dan-Dan,Lin, Yuan,Hu, Wei,Mao, Zong-Wan,Le, Xue-Yi
, p. 8721 - 8737 (2014/06/09)
Two new water-soluble copper(ii)-dipeptide complexes: [Cu(glygly)(PyTA)] ClO4·1.5H2O (1) and [Cu(glygly)(PzTA)]ClO 4·1.5H2O (2) (glygly = glycylglycine anion, PyTA = 2,4-diamino-6-(2′-pyridyl)-1,3,5-triazine and PzTA = 2,4-diamino-6- (2′-pyrazino)-1,3,5-triazine), utilizing two interrelated DNA base-like ligands (PyTA and PzTA), have been synthesized and characterized. The structure elucidation for 1 performed by single crystal X-ray diffraction showed a one dimensional chain conformation in which the central copper ions arrange in a five-coordinate distorted square-pyramidal geometry. Spectroscopic titration, viscosity and electrophoresis measurements revealed that the complexes bound to DNA via an outside groove binding mode, and cleaved pBR322 DNA efficiently in the presence of ascorbate, probably via an oxidative mechanism with the involvement of OH and O2-. Notably, the complexes exhibited considerable in vitro cytotoxicity against four human carcinoma cell lines (HepG2, HeLa, A549 and U87) with IC50 values ranging from 41.68 to 159.17 μM, in addition to their excellent SOD mimics (IC50 ～ 0.091 and 0.114 μM). Besides, multispectroscopic evidence suggested their HSA-binding at the cavity containing Trp-214 in subdomain IIA with moderate affinity, mainly via hydrophobic interaction. Further, the molecular docking technique utilized for ascertaining the mechanism and mode of action towards DNA and HSA theoretically verified the experimental results.
INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS
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Page/Page column 54-55, (2009/06/27)
Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject.
