127291-00-3

Upstream product

• 127290-97-5 benzyl 3-O-(methyl (2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate))-18β-glycyrrhetinate 
• 471-53-4 enoxolone 
• 6738-17-6 O-benzyl-N,N'-dicyclohexylisourea 
• 533934-74-6 (2S,3S,4S,5R,6R)-1-methyl-3,4,5,6-tetra-hydroxy-tetrahydro-2H-pyran-methylester 
• 150608-11-0 methyl 1,2,3,4-tetra-O-benzoyl-β-D-glucopyranuronate 
• 100-39-0 benzyl bromide 
• 169557-99-7 2,3,4-tri-O-benzoyl-1-deoxy-1-(2,2,2-trichloro-1-iminoethoxy)-α-D-glucopyranuronate, methyl ester 
• 51984-75-9 benzyl (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate 

Downstream Products

• 34096-83-8 1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid 
• 127291-07-0 succinimidyl N-<3β-(tert-butylglucuron-1'β-yl)-glycyrrhetyl>-Amcha 
• 127291-03-6 benzyl N-<3β-(tert-butylglucuron-1'β-yl)-glycyrrhetyl>-Amcha 
• 127316-66-9 benzyl N-<3β-(tert-butylglucuron-1'β-yl)-glycyrrhetyl>-glycinate 
• 127291-05-8 N-<3β-(tert-butylglucuron-1'β-yl)-glycyrrhetyl>-Amcha 
• 127291-01-4 benzyl 3β-(tert-butylglucuron-1'β-yl)-glycyrrhetate 

Relevant academic research and scientific papers

Chemical synthesis method of glycyrrtinic acid 3-O-mono-beta-D-glucuronide (GAMG)

The invention discloses a chemical synthesis method of glycyrrtinic acid 3-O-mono-beta-D-glucuronide (GAMG), and belongs to the fields of organic synthesis, medicinal chemistry, and food science. Abundant and cheap glycyrrhetinic acid is taken as the primary raw material, and GAMG is simply and easily synthesized by following five steps: carboxyl to benzyl ester conversion, glycosidation between C3 hydroxyl groups and a fully benzoylated methyl glucuronate glycosyl donor, methyl removal, benzoyl removal, and benzyl removal. The raw materials and reagents are cheap, the reaction conditions aremild, the operation is simple, the yield is good, and the GAMG chemical synthesis method is feasible.