1272972-07-2Relevant academic research and scientific papers
Three-component bicyclization providing an expedient access to pyrano[2′,3′:5,6]pyrano[2,3- b ]pyridines and its derivatives
Tu, Xing-Jun,Fan, Wei,Hao, Wen-Juan,Jiang, Bo,Tu, Shu-Jiang
, p. 647 - 651 (2014)
A new three-component bicyclization for the efficient synthesis of a fused pyrano[2,3-b]pyridine library has been developed. The syntheses were achieved by reacting diverse C,O-containing nucleophiles, aldehydes, and 2-aminoprop-1-ene-1,1,3-tricarbonitrile under microwave irradiation, providing 50 examples of chemically and biomedically significant pyrano[2,3-b]pyridine analogues with the concomitant formation of two new rings and four σ bonds. This procedure features short reaction times, low-cost, and easily available starting materials, reliable scalability and mild reaction conditions, as well as operational simplicity.
Synthesis of some new chromene derivatives, part 6
Fadda,Youssif
experimental part, p. 677 - 694 (2011/04/15)
Reactions of 2-amino-5-oxo-2-phenyl-5,6,7,8-tetrahydro-4H-chromen-3- carbonitrile (1a) with a variety of reagents leading to the synthesis of chromens have been investigated to explore the use of this exceptionally reactive nitrile in heterocyclic synthes
