107752-89-6Relevant academic research and scientific papers
Introduction of taurine (2-aminoethanesulfonic acid) as a green bio-organic catalyst for the promotion of organic reactions under green conditions
Shirini, Farhad,Daneshvar, Nader
, p. 110190 - 110205 (2016)
Taurine (2-aminoethanesulfonic acid), a semi-essential amino acid that exists in the human body and numerous other living creatures, is used as a green bio-organic catalyst for the promotion of the Knoevenagel reaction between aldehydes and malononitrile. In the same way, tetraketones can also be produced through a Knoevenagel reaction, followed by Michael addition. 2-Amino-3-cyano-4H-pyran derivatives are simply prepared via a three-component reaction in the presence of taurine as the catalyst. All these reactions are performed in water, a green solvent. The advantages of using of taurine as the catalyst are it is environmentally friendly, low cost, commercially available, easy to separate from the reaction mixture, and has high reusability. Use of this catalyst results in acceptable reaction times, high yields and high purities of the obtained products without utilizing any organic solvents.
Evaluation of magnetically recyclable nano-Fe3O4 as a green catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono and bis 1,4-dihydropyridine derivatives
Amirheidari, Bagher,Seifi, Mohammad,Abaszadeh, Mehdi
, p. 3413 - 3423 (2016)
Magnetically separable Fe3O4 nanoparticles were used as an environmental friendly catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono- and bis-1,4-dihydropyridine derivatives via three-component reactions of aromatic aldehydes and malononitrile with cyclic β-dicarbonyls or cyclic β-enaminoketones respectively. These reactions were carried out in EtOH and at reflux. Fe3O4 nanoparticles can be magnetically separated from the reaction mixture by a magnet and recycled without significant loss of catalytic activity.
The implication of electrocatalysis in MCR strategy: Electrocatalytic multicomponent transformation of cyclic 1,3-diketones, aldehydes and malononitrile into substituted 5,6,7,8-tetrahydro-4H-chromenes
Elinson, Michail N.,Dorofeev, Alexander S.,Feducovich, Sergey K.,Gorbunov, Sergey V.,Nasybullin, Ruslan F.,Miloserdov, Fedor M.,Nikishin, Gennady I.
, p. 4335 - 4339 (2006)
The electrochemically induced catalytic multicomponent transformation of cyclic 1,3-diketones, aldehydes and malononitrile in alcoholic solvents results in the formation of substituted 5,6,7,8-tetrahydro-4H-chromenes in 85-95% yields. The reaction is perf
Novel type of SO3H–functionalized nano-titanium dioxide as a highly efficient and recyclable heterogeneous nanocatalyst for the synthesis of tetrahydrobenzo[b]pyrans
Shamsi, Taiebeh,Amoozadeh, Ali,Sajjadi, S. Maryam,Tabrizian, Elham
, (2017)
n-Butylsulfonated nano-titania (n-TiO2-NH-(CH2)4-SO3H) as a highly efficient and reusable nanocatalyst was prepared by grafting 2,4-toluene diisocyanate as a bi-functional covalent linker onto a nano-titania sup
Nanostructured coumarin-based cobalt complex as an efficient, heterogeneous and recyclable catalyst for the three-component synthesis of benzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives
Sharghi, Hashem,Razavi, Seyyede Faeze,Aberi, Mahdi,Sabzalizadeh, Fatemeh,Karbalaei-Heidari, Hamid Reza
, p. 1641 - 1655 (2021)
Abstract: An improved one-pot three-component reaction of carbonyl compounds (dimedon, 4-hydroxy coumarin and 1,3-cyclohexadion) with malononitrile and aryl aldehydes in aqueous media (H2O:EtOH) as a solvent with short reaction time for the synthesis of benzo[b]pyran and 3,4- dihydropyrano[c]chromane derivatives by using nanostructured coumarin-based cobalt complex as an efficient heterogeneous catalyst. The salient features of this new protocol include simple procedure, high yields, easy isolation of products without need to column chromatography and short reaction times. Also, the nanocatalyst was recovered by adding EtOH and reused five times without significant loss of its catalytic activity. Biological impact assessments of the complex were conducted by DNA cleavage ability assay and eukaryotic cell toxicity measurement. Although the complex showed single-strand DNA breakage under oxidative conditions, its high polar nature revealed a marked decrease in cell toxicity data due to the restriction on cell entry. Graphic abstract: [Figure not available: see fulltext.]
Facile synthesis of functionalized 6-cyano-2-oxa-7-azabicyclo[4.1.0]hept-3-en-1-yl acetates: A catalyst free approach to access the pyran fused 2-acetoxy-NH-aziridines
Mukherjee, Prasun,Das, Asish R.
, p. 132 - 139 (2015)
Novel 6-cyano-2-oxa-7-azabicyclo[4.1.0]hept-3-en-1-yl acetate scaffolds were synthesized directly from 2-amino-3-cyano-4-H-pyrans as well as 2-amino-3-cyano-spiropyrans using iodobenzene diacetate (PIDA) as oxidant at room temperature in the absence of an
Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities
Dutta, Arup,Rahman, Noimur,Kumar, John Elisa,Rabha, Jintu,Phukan, Tridip,Nongkhlaw, Rishanlang
, p. 263 - 278 (2021)
A convenient and eco-friendly, one-pot synthetic protocol for pharmaceutically important pyran-based heterocyclic compounds is repeated herein. The reactions were carried out at room temperature in a water–ethanol solvent mixture under direct irradiation
A cesium fluoride promoted efficient and rapid multicomponent synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives
Wagh, Yogesh B.,Tayade, Yogesh A.,Padvi, Swapnil A.,Patil, Bhupesh S.,Patil, Nilesh B.,Dalal, Dipak S.
, p. 1273 - 1277 (2015)
A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available CsF as a catalyst in the reaction of mal
A cytochrome c-urea functionalized dipeptide conjugate: An efficient HBD framework to synthesize 4: H -pyrans via one-pot multicomponent reaction
Saini, Sanjeev,Mayank,Kaur, Navneet,Singh, Narinder
, p. 956 - 968 (2020)
This work is focused on the development of an efficient and green protocol for the one-pot multicomponent synthesis of a series of 4H-pyran derivatives. Herein, a protein-peptide conjugate (SS1-Cyt. c) is synthesized and characterized using Circular Dichr
Efficient Synthesis of 4H-Pyran and Spiro-Oxindole Derivatives Based on Al2O3/V2O5 Nanocomposite as Catalyst
Hassani, H.,Jahani, Z.,Poor, H. H.
, p. 491 - 497 (2020)
Abstract: A simple and eco-friendly catalytic alternative has been proposed for one-potthree-component synthesis of 4H-pyrane andspiro-oxindole derivatives, as two important classes of potentially bioactivecompounds, in the presence of a catalytic amount
