1274885-07-2

Upstream product

• 1274887-19-2 C₁₇H₂₀N₄O 
• 1274887-23-8 C₂₅H₂₅F₃N₄O₂ 
• 173666-23-4 3-(benzyloxymethyl)acrylonitrile 
• 627527-23-5 1-bromo-3-methoxy-5-(trifluoromethyl)benzene 
• 349-55-3 5-(trifluoromethyl)-m-anisidine 
• 60656-87-3 benzyloxyacetoaldehyde 

Downstream Products

• 1274885-08-3 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-methanol 
• 1274885-09-4 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile 
• 1274885-10-7 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetic acid methyl ester 
• 1274885-12-9 N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide 

Relevant academic research and scientific papers

Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines

The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I) Wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

SUBSTITUTED N-PHENYL-1-(4-PYRIDINYL)-1H-PYRAZOL-3-AMINES

The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I): wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.