127498-24-2

Basic information

• Product Name: (1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide
• Synonyms: (1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide
• CAS NO: 127498-24-2
• Molecular Weight: 273.332
• Mol File: 127498-24-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide(127498-24-2)
• EPA Substance Registry System: (1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide(127498-24-2)

Safety Data

• Hazardous Substances Data: 127498-24-2(Hazardous Substances Data)

Upstream product

• 464-78-8 (1S)-(+)-ketopinic acid 
• 54371-12-9 ketopinic acid chloride 
• 95-55-6 2-amino-phenol 

Downstream Products

• 128013-81-0 (1S,4R)-2-[(E)-(R)-2-(4-Methoxy-phenyl)-1-phenyl-ethylimino]-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide 
• 128013-83-2 (1S,4R)-2-[(E)-(R)-Cyclohexyl-phenyl-methylimino]-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide 
• 128013-82-1 (1S,4R)-2-[(E)-(R)-1,2-Diphenyl-ethylimino]-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide 
• 128013-79-6 (1S,4R)-7,7-Dimethyl-2-[(E)-(R)-2-methyl-1-phenyl-propylimino]-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide 
• 128013-80-9 (1S,4R)-7,7-Dimethyl-2-[(E)-(R)-1-phenyl-ethylimino]-bicyclo[2.2.1]heptane-1-carboxylic acid (2-hydroxy-phenyl)-amide 
• 127498-25-3 10-(N-o-hydroxyphenylamide)-N-benzyl-7,7-dimethyl-dicyclo-<2,2,1>-heptane-2-imine 
• 144757-96-0 {[(1S,4R)-1-(2-Hydroxy-phenylcarbamoyl)-7,7-dimethyl-bicyclo[2.2.1]hept-(2E)-ylideneamino]-methyl}-phosphonic acid diethyl ester 

Relevant articles and documents

Alkylation of chiral phosphonoglycine equivalents: Asymmetric synthesis of diethyl α-amino-α-alkyl-phosphonates

A model was developed to rationalize the experimental results of the alkylation of chiral phosphonoglycine equivalents yielding α-amino-α-alkyl-phosphonates. The model studies, carried out using semiempirical calculations, have emphasized the role of the chelating effects in influencing the diastereoselectivity of the alkylation step. Chelation can be optimized by tuning the functionality of the substituent at carbon C-1 of the camphor skeleton. By employing 2d, as suggested by the modelling, a major improvement in the enantiomeric excesses of compounds 5 (R = CH3, C2H5) was obtained.