Tetrahedron p. 1817 - 1826 (1995)
Update date:2022-07-30
Topics:
Cabella, Giulia
Jommi, Giancarlo
Pagliarin, Roberto
Sello, Guido
Sisti, Massimo
A model was developed to rationalize the experimental results of the alkylation of chiral phosphonoglycine equivalents yielding α-amino-α-alkyl-phosphonates. The model studies, carried out using semiempirical calculations, have emphasized the role of the chelating effects in influencing the diastereoselectivity of the alkylation step. Chelation can be optimized by tuning the functionality of the substituent at carbon C-1 of the camphor skeleton. By employing 2d, as suggested by the modelling, a major improvement in the enantiomeric excesses of compounds 5 (R = CH3, C2H5) was obtained.
View MoreShijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
shandong lukang animal & plant drug trading co.,ltd.
Contact:15853765968
Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Xuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
suzhou BetterBioChem Co., Ltd.
website:http://www.betterbiochem.com
Contact:+86-18013506594
Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China
Feiyang Biotechnology Co., Ltd.
Contact:+86-533-7866339
Address:Qilu Chemistry Park, 200m north of Management Community Building of Park
Doi:10.1016/S0040-4039(01)89004-3
(1989)Doi:10.1021/jo00301a043
(1990)Doi:10.1021/jo1024927
(2011)Doi:10.1002/aoc.1744
(2011)Doi:10.1021/ol200395e
(2011)Doi:10.1002/anie.201005044
(2011)