127517-82-2

Upstream product

• 71998-69-1 (S)-4-benzyloxy-1,2-butanediol 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 100-39-0 benzyl bromide 
• 82780-39-0 (S)-4-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 127517-83-3 (S)-diethyl <<3-(benzyloxy)-1-<methyl>propoxy>methyl>phosphonate 
• 151223-13-1 (S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1,2,4-butanetriol 
• 151223-14-2 (S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methoxymethyl)-1,2,4-butanetriol 
• 151223-35-7 (S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol 
• 151223-49-3 (S)-1-<4-benzyloxy-2-<(diisopropylphosphono)methoxy>butyl>cytosine 
• 151223-42-6 (S)-1-amino-9-<4-(benzyloxy)-2-<(diisopropylphosphono)methoxy>butyl>-6-chloropurine 
• 127517-84-4 ((S)-3-Benzyloxy-1-hydroxymethyl-propoxymethyl)-phosphonic acid diethyl ester 
• 127517-85-5 (S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate 

Relevant academic research and scientific papers

Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives

Compounds are provided that generally have the structure BCH2 CH(R)OCH2 P(O)(OH)2, wherein B is a purinyl or pyrimidinyl base and R is C1-2 alkyl substituted with azido or amino, straight or branched alkenyl of

Synthesis and antiviral activity of 2'-substituted 9-[2- (phosphonomethoxy)ethyl]guanine analogues

A series of 2'-substituted derivatives of 9-[2- (phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and evaluated in vitro for anti-human immunodeficiency virus (HIV) activity in the XTT assay and for anti-herpes activity in the plaque reducti

Synthesis and Antiviral Activity of (S)-9-guanine

The synthesis of (S)-9-guanine (3), starting from (S)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (4), is described.Alkylation of trityl derivative 7 with (diethylphosphono)methyl triflate provided phosphonate 8, whi