127555-82-2

Upstream product

• 127555-44-6 1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one 
• 75-77-4 chloro-trimethyl-silane 
• 144-55-8 sodium hydrogencarbonate 
• 62-53-3 aniline 
• 21093-56-1 (3-Chloromethyl-pyridin-2-yl)-phenyl-amine; hydrochloride 
• 127555-39-9 1,3-dihydro-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one 
• 128271-32-9 Phenyl-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 
• 21093-54-9 2-Phenylamino-3-hydroxymethylpyridine 
• 16344-24-4 2-(phenylamino)nicotinic acid 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 127555-23-1 1,3-Dihydro-3-fluoro-3-methyl-1-phenyl-2H-pyrrolo [2,3-b]pyridin-2-one 
• 128271-24-9 3-Ethyl-3-methyl-1-phenyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one 
• 127555-25-3 1,3-dihydro-3,3-dimethyl-1-phenyl-2H-pyrrolo<2,3-b>pyridin-2-one 

Relevant academic research and scientific papers

Heterobicyclic compounds having antiinflammatory activity

Heterobicyclic and heterocyclic intermediate compounds and their use in treating inflammation, hyperproliferative skin conditions such as psoriasis and allergy are disclosed.

Substituted 1,3-Dihydro-2H-pyrrolopyridin-2-ones as Potential Antiinflammatory Agents

A series of analogues based on the 1,3-dihydro-2H-pyrrolopyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant-induced arthritic rat model (AAR).Several members of this series additionally exhibit an inhibitory effect on the in vivo production of prostaglandin- and leukotriene-derived products or arachidonic acid metabolism although these compounds exhibit no significant inhibitory activity against the cyclooxygenase and 5-lipoxygenase enzymes in vitro.Structure-activity relationships in this series are discussed.