127572-56-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of isoxazole-based CK1 inhibitors modified with chiral pyrrolidine scaffolds
Luxenburger, Andreas,Schmidt, Dorian,Ianes, Chiara,Pichlo, Christian,Krüger, Marc,von Drathen, Thorsten,Brunstein, Elena,Gainsford, Graeme J.,Baumann, Ulrich,Knippschild, Uwe,Peifer, Christian
, (2019/03/19)
In this study, we report on the modification of a 3,4-diaryl-isoxazole-based CK1 inhibitor with chiral pyrrolidine scaffolds to develop potent and selective CK1 inhibitors. The pharmacophore of the lead structure was extended towards the ribose pocket of
Nano-copper catalysed highly regioselective synthesis of 2,4-disubstituted pyrroles from terminal alkynes and isocyanides
Tiwari, Dipak Kumar,Pogula, Jaya,Sridhar,Tiwari, Dharmendra Kumar,Likhar, Pravin R.
, p. 13646 - 13649 (2015/09/02)
Nano-copper(0) stabilized on alumina prepared from Cu-Al hydrotalcite has been reported for completely regioselective synthesis of 2,4-disubstituted pyrroles from unactivated terminal aromatic/aliphatic alkynes and isocyanides. The reaction is operational
Application of 2-Substituted Vinamidinium Salts to the Synthesis of 2,4-Disubstituted Pyrroles
Gupton, John T.,Krolikowski, Dale A.,Yu, Richard H.,Riesinger, Steve W.,Sikorski, James A.
, p. 4735 - 4740 (2007/10/02)
A variety of 2-substituted vinamidinium salts react with α-amino acid esters under basic conditions to produce 2-carbethoxy-4-substituted-pyrroles in good yield.The overall process represents a short and efficient synthesis of highly functionalized pyrrol
