127709-19-7

Basic information

• Product Name: methyl 4-fluoro-α-hydroxyphenylacetate
• Synonyms: methyl 4-fluoro-α-hydroxyphenylacetate
• CAS NO: 127709-19-7
• Molecular Weight: 184.167
• Mol File: 127709-19-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: methyl 4-fluoro-α-hydroxyphenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-fluoro-α-hydroxyphenylacetate(127709-19-7)
• EPA Substance Registry System: methyl 4-fluoro-α-hydroxyphenylacetate(127709-19-7)

Safety Data

• Hazardous Substances Data: 127709-19-7(Hazardous Substances Data)

Upstream product

• 684-93-5 1-methyl-1-nitrosourea 
• 32222-45-0 4-fluoromandelic acid 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 
• 133721-87-6 2-(4-fluorophenyl)-2-hydroxyacetonitrile 
• 1424934-11-1 C₁₅H₁₇FOSi 
• 1504663-20-0 [dimethylphenylsilyl(4-fluorophenyl)methoxy]trimethylsilane 
• 459-57-4 4-fluorobenzaldehyde 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 156276-23-2 methyl (p-fluorobenzoyl)formate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 

Downstream Products

• 32222-46-1 (4-fluoro-phenyl)-hydroxy-acetic acid methyl ester 
• 139520-78-8 (S)-(+)-methyl 2-acetoxy-2-(4-fluorophenyl)acetate 
• 1359987-65-7 methyl 2-acetoxy-2-(4-fluorophenyl)acetate 
• 1186200-76-9 methyl 2-(acetylthio)-2-(4-fluorophenyl)acetate 
• 71783-54-5 methyl 2-bromo-2-(4-fluorophenyl)acetate 
• 959025-07-1 2-(4-fluorophenyl)-2-hydroxyacetamide 
• 1301601-52-4 C₁₃H₁₃FO₄ 
• 1301601-41-1 methyl 2-(4-fluorophenyl)-2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)acetate 
• 1301601-27-3 C₁₃H₁₅FO₅ 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 660432-05-3 N-[methyl] N-[methoxy] 2-hydroxy-2-(4-fluorophenyl)acetamide 
• 1036273-29-6 methyl 2-(4-fluorophenyl)-2-chloroacetate 

Relevant articles and documents

Direct Aerobic α-Hydroxylation of Arylacetates for the Synthesis of Mandelates

Aerobic α-hydroxylation of α-methylene esters has proven challenging due to overoxidation and hydrolysis of the materials. In this article, KOtBu-promoted TBAB-catalyzed α-hydroxylation of α-methylene aryl esters using O2as the oxyge

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.

Ru-MACHO-Catalyzed Highly Chemoselective Hydrogenation of α-Keto Esters to 1,2-Diols or α-Hydroxy Esters

A ruthenium pincer catalyst has been shown to be highly effective for the hydrogenation of a wide range of α-keto esters, affording either diols or hydroxy esters depending on the choice of reaction conditions. Strong base, high temperature, and pressure favor the formation of diols whilst the opposite is true for the hydroxy esters.