32222-46-1

Basic information

• Product Name: (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester
• Synonyms: (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester;(R)-Ethyl 2-(4-fluorophenyl)-2-hydroxyacetate
• CAS NO: 32222-46-1
• Molecular Formula: C10H11FO3
• Molecular Weight: 198
• Mol File: 32222-46-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 268.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.272±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.12±0.20(Predicted)
• CAS DataBase Reference: (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester(32222-46-1)
• EPA Substance Registry System: (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester(32222-46-1)

Safety Data

• Hazardous Substances Data: 32222-46-1(Hazardous Substances Data)

Usage

General Description

"(R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester" is an organic compound that belongs to the ester family. It is composed of an ethyl ester group, a hydroxy group, and a (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid group. The compound is commonly used in organic synthesis and pharmaceutical research due to its potential pharmacological activities. It has been implicated in studies related to its anti-inflammatory, analgesic, and anti-cancer properties. Additionally, it is used as a building block in the synthesis of various pharmaceuticals and biologically active compounds. The compound's unique structure and reactivity make it a valuable asset in the development of new drugs and chemical compounds.

Upstream product

• 67-56-1 methanol 
• 32222-45-0 4-fluoromandelic acid 
• 684-93-5 1-methyl-1-nitrosourea 
• 156276-23-2 methyl (p-fluorobenzoyl)formate 
• 219564-79-1 methyl 2-diazo-2-(4-fluorophenyl)acetate 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 74-88-4 methyl iodide 
• 459-57-4 4-fluorobenzaldehyde 
• 108-05-4 vinyl acetate 
• 127709-19-7 methyl 4-fluoro-α-hydroxyphenylacetate 
• 133721-87-6 2-(4-fluorophenyl)-2-hydroxyacetonitrile 
• 144758-62-3 Butyric acid (4-fluoro-phenyl)-methoxycarbonyl-methyl ester 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 

Downstream Products

• 32222-45-0 (R)-2-(4-fluorophenyl)-2-hydroxyacetic acid 
• 63096-35-5 (4-fluoro-phenyl)-hydroxy-acetic acid methyl ester 
• 1186200-76-9 methyl 2-(acetylthio)-2-(4-fluorophenyl)acetate 

Relevant articles and documents

Direct Aerobic α-Hydroxylation of Arylacetates for the Synthesis of Mandelates

Aerobic α-hydroxylation of α-methylene esters has proven challenging due to overoxidation and hydrolysis of the materials. In this article, KOtBu-promoted TBAB-catalyzed α-hydroxylation of α-methylene aryl esters using O2as the oxyge

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).