127744-29-0Relevant academic research and scientific papers
Biosynthesis of archaebacterial ether lipids. Formation of ether linkages by prenyltransferases
Zhang, Donglu,Dale Poulter
, p. 1270 - 1277 (1993)
Biosynthesis of (R)-2,3-di-Ophytanylglycerol (1), the core lipid of the membranes in the strict anaerobe Methanobacterium thermoautotrophicum, was studied in cell-free preparations. Two prenyltransferase activities were separated by ultracentrifugation. T
Investigating the Individual Importance of the Pam2Cys Ester Motifs on TLR2 Activity
Brimble, Margaret A.,Dunbar, P. Rod,Kelch, Inken D.,Li, Freda F.,Lu, Benjamin L.,Williams, Geoffrey M.
, p. 5415 - 5423 (2021/10/25)
TLR2 agonists are at the forefront of vaccine research for a plethora of diseases, in particular they offer a promising tool for the treatment of cancer. A detailed knowledge of their structure–activity relationship informs the methodical design of vaccin
IMMUNOMODULATING POLYNUCLEOTIDE CONJUGATES AND METHODS OF USE
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Page/Page column 157, (2020/05/26)
Provided herein is a conjugate for modulating a natural killer cell or myeloid cell, comprising a targeting moiety and an immunomodulating polynucleotide. Also provided herein is a pharmaceutical composition for modulating a natural killer cell or myeloid cell, comprising a conjugate comprising a targeting moiety and an immunomodulating polynucleotide, and a pharmaceutically acceptable excipient. Additionally provided herein are methods of their use for modulating a natural killer cell or myeloid cell and treating a proliferative disease.
POLYNUCLEOTIDE CONSTRUCTS
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Page/Page column 75; 76, (2018/03/09)
Disclosed are polynucleotide constructs having a strand linked to a moiety carrying one or more auxiliary moieties. Also disclosed are polynucleotide constructs interrupted with a sugar analogue, and polynucleotide constructs with stereochemical^ enriched phosphorothioates. The polynucleotide constructs may be provided as hybridized polynucleotide constructs. Also featured are methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell by contacting the cell with the disclosed polynucleotide construct or hybridized polynucleotide construct.
IMMUNOMODULATING POLYNUCLEOTIDES, ANTIBODY CONJUGATES THEREOF, AND METHODS OF THEIR USE
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Paragraph 1134, (2018/11/21)
Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use.
Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid
Gajewiak, Joanna,Tsukahara, Ryoko,Fujiwara, Yuko,Tigyi, Gabor,Prestwich, Glenn D.
supporting information; experimental part, p. 1111 - 1114 (2009/04/07)
An efficient enantioselective synthesis of sn-2-aminooxy (AO) analogues of lysophosphatidic acid (LPA) that possess palmitoyl and oleoyl acyl chains Is presented. Both sn-2-AO LPA analogues are agonists for the LPA1, LPA2, and LPAsu
SYNTHESIS OF(2R) AND (2S)-BENZYL-2,3-EPOXYPROPYL ETHER FROM A COMMON PRECURSOR: O-BENZYL-L-SERINE
Witt, P. De,Misiti, D.,Zappia, G.
, p. 5505 - 5506 (2007/10/02)
The (2R) and (2S)-benzyl-epoxypropyl ether are obtained from commercially available O-benzyl-serine, via nitrosation and Mitsunobu reactions to afford the chiral precursors of the above epoxy ethers.
