573673-85-5Relevant academic research and scientific papers
Investigating the Individual Importance of the Pam2Cys Ester Motifs on TLR2 Activity
Brimble, Margaret A.,Dunbar, P. Rod,Kelch, Inken D.,Li, Freda F.,Lu, Benjamin L.,Williams, Geoffrey M.
, p. 5415 - 5423 (2021/10/25)
TLR2 agonists are at the forefront of vaccine research for a plethora of diseases, in particular they offer a promising tool for the treatment of cancer. A detailed knowledge of their structure–activity relationship informs the methodical design of vaccin
Liposomes containing tetraether lipid derivatives
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Page/Page column 17, (2014/04/04)
The present invention relates to liposomes comprising a tetraether lipid of formula (1) or a salt thereof and at least one sterol, wherein the molar ratio of tetraether lipid to sterol is from 1 : 1 to 1 : 10.
ANALOGUES OF PHOSPHATIDYLINOSITOL MANNOSIDES
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Page/Page column 24-25, (2008/12/06)
The invention relates to compounds which are immunomodulatory compounds and, in particular, can induce IL-12 secretion. The invention also relates to compositions containing the compounds, precursors, and prodrugs of these compounds, use of these compounds as adjuvants in combination with vaccines, and use of these compounds for treatment of diseases or conditions relating to infection, atopic disorders, or cancer.
Phosphatidylinositol mannoside ether analogues: Syntheses and interleukin-12-inducing properties
Ainge, Gary D.,Parlane, Natalie A.,Denis, Michel,Dyer, Blake S.,Haerer, Andrea,Hayman, Colin M.,Larsen, David S.,Painter, Gavin F.
, p. 5291 - 5296 (2008/02/07)
(Chemical Equation Presented) Phosphatidylinositol mannosides (PIMs) isolated from mycobacteria have been identified as an important class of glycolipids with significant immune modulating properties. We present here the syntheses of phosphatidylinositol
