147363-14-2

Upstream product

• 29333-41-3 methyl 3,5-bis(bromomethyl)benzoate 
• 147363-13-1 N-Boc-O-allyl-L-tyrosine amide N,N-di-Boc-amide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 147363-23-3 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate 
• 147363-12-0 tert-butyl (S)-(3-(4-(allyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 

Downstream Products

• 127802-97-5 (S)-O-allyl-tyrosine methyl ester 

Relevant academic research and scientific papers

Practical Synthesis of a Highly Enantioselective Receptor for Peptides

A practical synthesis of a highly enantioselective, C3-symmetric host molecule (2) has been developed.The basic strategy is a significant improvement over the relatively lenghty previous synthesis and involves direct addition of a Boc-tyrosine amide anion derivative 4 to methyl 3,5-bis(bromomethyl)benzoate to give an advanced intermediate (5).The final step, a triple macrolactamization, closes three 19-membered rings simultaneously to produce the bridged macrotricyclic receptor in 70-80percent yield.