1278985-06-0

Upstream product

• 139871-31-1 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxy-5-methylpyrimidine 
• 120129-83-1 2,4-dimethoxy-5,6-dimethylpyrimidine 
• 914824-72-9 6-[(3-benzyloxy-2-benzyIoxymethyl-2-methyloxalyI)propyl]-2,4-dimethoxy-5-methylpyrimidine 
• 77356-14-0 1,3-dibenzyloxy-2-propanone 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

NEW 6-SUBSTITUTED PYRIMIDINE DERIVATIVES

The Invention deals with new 6-substituted pyrimidine derivatives of the general formula (I): where: R1 = methyl or H or CH2X, X = Br, F, Cl R2 = oxygen or methoxy or OH R3 = oxygen or methoxy or OH R4 = H or methyl or (CH2)nY, n = 2 or 3, Y = OH or Br or F or Cl or OCOCH3, R5 = (II), (III), R6 and R7 can independently of each other be H, CH2Z, CH2OH, CH2OCH2Ph, CH2OCPh2PhOCH3; Z=Br, F, Cl; Where, if R5 = (IV) and if one of R6 and R7 CH2Z (Z = Br, F, Cl), then R5 and R1 form with CH2A, A = Cl, Br, F a substituted unsaturated 5-membered ring and, provided that R6 or R7 = H, then the other of them cannot be H; and R8, R9, R10 = OH, CH2OCH2Ph, H, OC2O3CH3, CH2OH, CH2OCPh2PhOCH3, CH2OSO2PhCH3; and where F, regardless of which place it may take in the molecule, may appear in the form of radioisotope 18F; one of the carbons occupying any place in the compound of the general formula I may appear in the form of radioisotope 11C, just as an oxygen occupying any place in the compound of the general formula I may appear in the form of radioisotope 15O; the Invention also deals with their use as substrates in the Positron Emission Tomography (PET), as well as their use in tumor therapy. Formulae (I), (II), (III), (IV)