127926-24-3 Usage
General Description
N-(t-butoxycarbonyl)-1-carboxy-2-azabicyclo[2.1.1]hexane, also known as Boc-1-carboxy-2-azabicyclo[2.1.1]hexane, is a chemical compound with the molecular formula C12H19NO4. It is a derivative of azabicyclo[2.1.1]hexane, which is a bicyclic compound containing a nitrogen atom. The t-butoxycarbonyl (Boc) group is a protective group commonly used in organic chemistry to protect amines from unwanted reactions. Boc-1-carboxy-2-azabicyclo[2.1.1]hexane is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is important for drug discovery and development, as well as in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 127926-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,9,2 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 127926-24:
(8*1)+(7*2)+(6*7)+(5*9)+(4*2)+(3*6)+(2*2)+(1*4)=143
143 % 10 = 3
So 127926-24-3 is a valid CAS Registry Number.
127926-24-3Relevant articles and documents
Complex-induced proximity effects. Temperature-dependent regiochemical diversity in lithiation-electrophilic substitution reactions of N-BOC-2-azabicyclo[2.1.1]hexane. 2,4- and 3,5-methanoprolines.
Krow, Grant R,Herzon, Seth B,Lin, Guoliang,Qiu, Feng,Sonnet, Philip E
, p. 3151 - 3154 (2007/10/03)
[reaction: see text] Azabicycle 4 and sec-butyllithium/TMEDA afford the C(1) bridgehead alpha-lithio anion at 0 degrees C. Anion quenching with carbon dioxide, methyl chloroformate, or DMF provide the bridgehead acid 8a (N-BOC-2,4-methanoproline), ester 8b, or aldehyde 8c, respectively. By contrast, at -78 degrees C these same reagents give a mixture of regioisomeric methylene and bridgehead anions whose quenching leads to mixtures of regioisomeric methylene and bridgehead acids 6a/8a, esters 6b/8b, or aldehydes 6c/8c, respectively. The previously unknown 3,5-methanoproline was prepared as its N-BOC methyl ester 6b.