77422-38-9

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl N-benzoyl-1-azabicyclohexane-5-carboxylate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new medications with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, Methyl N-benzoyl-1-azabicyclohexane-5-carboxylate is utilized as a key component in the creation of pesticides and other agricultural chemicals, enhancing crop protection and yield.
Used in Fragrance and Flavor Industry:
Methyl N-benzoyl-1-azabicyclohexane-5-carboxylate is employed as a building block in the production of fragrances and flavors, capitalizing on its unique structure to create novel and complex scents and tastes.
Organic Chemistry Research:
Due to its unique structure and potent biological activities, Methyl N-benzoyl-1-azabicyclohexane-5-carboxylate is a valuable compound in the field of organic chemistry, used for research and development of new chemical entities with potential applications across various industries.

Upstream product

• 98-88-4 benzoyl chloride 
• 33646-32-1 methyl 2-benzamido-3-chloro-propanoate 
• 77422-37-8 methyl N-allyl-2-benzamidopropenoate 

Downstream Products

• 109794-96-9 cis-1-amino-3-(hydroxymethyl)cyclobutane-1-carboxylic acid 
• 116129-01-2 N-(t-butoxycarbonyl)-1-carbomethoxy-2-azabicyclo[2.1.1]hexane 
• 127926-24-3 2-(tert-butoxycarbonyl)-2-azabicyclo[2.1.1]hexane-1-carboxylic acid 
• 116129-05-6 methyl 2,4-methanopyroglutamate 
• 73550-55-7 Cis-ACBD 
• 73550-56-8 2-azabicyclo[2.1.1]hexane-1-carboxylic acid 

Relevant academic research and scientific papers

Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity

A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic acid derivative in flow. In spite of a higher molecular weight, 2,4-methanopyrrolidines were shown to have higher solubility in water and lower lipophilicity than pyrrolidines, important characteristics of bioactive molecules in drug design.

Efficient preparation of 2,4-methanoproline

Using a modification of the route described by Clardy and Hughes et al., 2,4-methanoproline hydrochloride (1) was prepared in four steps and 70% overall yield from DL-serine methyl ester.

Total Synthesis of Cyclobutane Amino Acids from Atelia herbert smithii

The syntheses of two amino acids from the seeds of the legume Atelia herbert smithii, 2,4-methanoproline and 2,4-methanoglutamic acid, are described.The synthesis of third amino acid, cis-1-amino-3-(hydroxymethyl)cyclobutanecarboxylic acid and subsequent

SYNTHESIS OF 2,4-METHANOPROLINE

An efficient synthesis of 2,4-methanoproline from serine is described.The cyclobutane is formed by a sensitized intramolecular photoaddition.