127940-83-4Relevant academic research and scientific papers
Stereoselective substituted pyrrolidine and cyclic ether synthesis by PhS migration
Caggiano, Lorenzo,Davies, John,Fox, David J.,Moody, David C.,Warren, Stuart
, p. 1648 - 1649 (2007/10/03)
The effect of substitution on heterocycle synthesis by a novel silica gel catalysed decarboxylative ring-closing reaction is shown to be stereospecific and dependent on the nature of the nitrogen substituent.
Synthesis of Cyclic Amines and Allylic Sulfides by Phenylthio Migration of β-Hydroxy Sulfides
Coldham, Iain,Warren, Stuart
, p. 1637 - 1656 (2007/10/02)
Rearrangement of β-hydroxy sulfides proceeds stereospecifically with capture of the episulfonium ion by the nitrogen atom of an amide.Almost quantitative yields of substituted pyrrolidines are obtained using a sulfonamide as the intramolecular nucleophile
STEREOCONTROLLED AMIDOCYCLISATIONS WITH PHENYLTHIO MIGRATION
Coldham, Iain,Warren, Stuart
, p. 5937 - 5940 (2007/10/02)
Rearrangement of β-hydroxysulphides proceeds through an episulphonium ion which can be captured intramolecularly by the nitrogen atom of carbamates, ureas, or sulphonamides to give single diastereoisomers of pyrrolidines.With a free amine no capture takes
