127941-02-0

Basic information

• Product Name: (3S,4R)-3-Methyl-4-phenylsulfanyl-1-(toluene-4-sulfonyl)-1-aza-spiro[4.5]decane
• CAS NO: 127941-02-0
• Molecular Weight: 415.621
• Mol File: 127941-02-0.mol

Chemical Properties

• CAS DataBase Reference: (3S,4R)-3-Methyl-4-phenylsulfanyl-1-(toluene-4-sulfonyl)-1-aza-spiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-3-Methyl-4-phenylsulfanyl-1-(toluene-4-sulfonyl)-1-aza-spiro[4.5]decane(127941-02-0)
• EPA Substance Registry System: (3S,4R)-3-Methyl-4-phenylsulfanyl-1-(toluene-4-sulfonyl)-1-aza-spiro[4.5]decane(127941-02-0)

Safety Data

• Hazardous Substances Data: 127941-02-0(Hazardous Substances Data)

Upstream product

• 127940-96-9 (2RS,3SR)-N-<3-hydroxy-2-methyl-3-<1-(phenylthio)cyclohexyl>propyl>tosylamide 
• 127940-96-9 (2RS,3RS)-N-<3-hydroxy-2-methyl-3-<1-(phenylthio)cyclohexyl>propyl>tosylamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 57768-35-1 1-(phenylthio)-1-cyclohexanecarboxaldehyde 
• 127940-85-6 (2R,3R)-3-Hydroxy-2-methyl-3-(1-phenylsulfanyl-cyclohexyl)-thiopropionic acid S-phenyl ester 
• 127940-83-4 (2RS,3RS)-3-hydroxy-2-methyl-3-<1-(phenylthio)cyclohexyl>propiononitrile 
• 127940-84-5 (1RS,2RS)-3-amino-2-methyl-1-<1-(phenylthio)cyclohexyl>propan-1-ol 
• 127940-83-4 (2RS,3SR)-3-hydroxy-2-methyl-3-<1-(phenylthio)cyclohexyl>propiononitrile 
• 127940-84-5 (1SR,2RS)-3-amino-2-methyl-1-<1-(phenylthio)cyclohexyl>propan-1-ol 

Relevant articles and documents

Synthesis of Cyclic Amines and Allylic Sulfides by Phenylthio Migration of β-Hydroxy Sulfides

Rearrangement of β-hydroxy sulfides proceeds stereospecifically with capture of the episulfonium ion by the nitrogen atom of an amide.Almost quantitative yields of substituted pyrrolidines are obtained using a sulfonamide as the intramolecular nucleophile

STEREOCONTROLLED AMIDOCYCLISATIONS WITH PHENYLTHIO MIGRATION

Rearrangement of β-hydroxysulphides proceeds through an episulphonium ion which can be captured intramolecularly by the nitrogen atom of carbamates, ureas, or sulphonamides to give single diastereoisomers of pyrrolidines.With a free amine no capture takes