127941-04-2Relevant academic research and scientific papers
Synthesis of Cyclic Amines and Allylic Sulfides by Phenylthio Migration of β-Hydroxy Sulfides
Coldham, Iain,Warren, Stuart
, p. 1637 - 1656 (2007/10/02)
Rearrangement of β-hydroxy sulfides proceeds stereospecifically with capture of the episulfonium ion by the nitrogen atom of an amide.Almost quantitative yields of substituted pyrrolidines are obtained using a sulfonamide as the intramolecular nucleophile
STEREOCONTROLLED AMIDOCYCLISATIONS WITH PHENYLTHIO MIGRATION
Coldham, Iain,Warren, Stuart
, p. 5937 - 5940 (2007/10/02)
Rearrangement of β-hydroxysulphides proceeds through an episulphonium ion which can be captured intramolecularly by the nitrogen atom of carbamates, ureas, or sulphonamides to give single diastereoisomers of pyrrolidines.With a free amine no capture takes
