128095-52-3

Basic information

• Product Name: 4-Methylumbelliferyl2,3,4-tri-O-acetyl-a-L-idopyranosiduronicacidmethylester
• Synonyms: 4-Methylumbelliferyl α-L-Idopyranosiduronic Acid Methyl Ester
• CAS NO: 128095-52-3
• Molecular Formula: C23H24O12
• Molecular Weight: 492.431
• Mol File: 128095-52-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Water (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-Methylumbelliferyl2,3,4-tri-O-acetyl-a-L-idopyranosiduronicacidmethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylumbelliferyl2,3,4-tri-O-acetyl-a-L-idopyranosiduronicacidmethylester(128095-52-3)
• EPA Substance Registry System: 4-Methylumbelliferyl2,3,4-tri-O-acetyl-a-L-idopyranosiduronicacidmethylester(128095-52-3)

Safety Data

• Hazardous Substances Data: 128095-52-3(Hazardous Substances Data)

Usage

Uses

4-Methylumbelliferyl α-L-Idopyranosiduronic Acid Methyl Ester is an intermediate in the synthesis of fluorogenic substrate in the assay of α-L-Iduronidase. A fluorimetric enzyme assay for the diagnosis of MPS II (Hunter disease).

Upstream product

• 101014-65-7 methyl (4′-methylumbelliferyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid)urinate 
• 7355-18-2 (2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 128095-50-1 4-methylcoumarin-7-yl-2,3,4-tri-O-acetyl-α-L-iduronic acid methyl ester 
• 56768-32-2 1-bromo-2,3,4-tri-O-acetyl-α-D-galactopyranuronic acid methyl ester 
• 5980-33-6 sodium 4-methylumbelliferonate 
• 929549-08-6 3,4,5-triacetoxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 67-56-1 methanol 
• 6160-80-1 4-methylumbelliferyl-β-D-glucuronide 
• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 

Relevant articles and documents

Practical Synthesis of the Fluorogenic Enzyme Substrate 4-Methylumbelliferyl α- L -Idopyranosiduronic Acid

A practical and concise synthesis of 4-methylumbelliferyl α- l -idopyranosiduronic acid, a fluorogenic enzyme substrate diagnostic for α- l -iduronidase, was accomplished. It features successive radical bromination and radical reduction of easily accessible methyl 4-methyl umbelliferyl-2,3,4-tri- O -acetyl-β- d -glucouronate in four steps with 28percent overall yield.

AN ESTERIFICATION/SAPONIFICATION-BASED METHOD FOR LIPOSOMAL LOADING

Described herein is a method for loading a hydrophilic compound into liposomes after addition of an alkylester group to form an esterified compound. After loading, the alkylester is hydrolyzed to reform the hydrophilic compound inside the liposomes. Also described is a method for loading drugs under a glucuronide methylester form into liposomes. The glucuronide methylester form of the drug is saponified to a glucuronide form of the drug inside the liposomes for better drug retention. The glucuronide residue conjugated to drugs can be removed inside cells to regenerate the parental drug upon cell uptake, liposomal degradation and enzyme hydrolysis. In case of cancer, this method can be used to safely deliver drugs to tumors.