128156-57-0Relevant academic research and scientific papers
Extending the scope of chromium - Manganese redox-coupled reactions: A one-pot synthesis of benzoxazoles
Hari,Karan,Rodrigues,Miller
, p. 991 - 996 (2001)
A critically important strategy for synthetic chemistry is the development of domino processes: those capable of concatenating multiple transformations into a single step. Such transformations not only provide an increase in synthetic efficiency, but also imply the development of a significant degree of mechanistic understanding. We report herein a new domino reaction, in which a chromium-manganese redox couple is employed both to catalytically reduce an o-hydroxy nitroarene and to oxidatively cyclize a subsequently formed imine. We find that the reaction is most effective for starting o-hydroxy nitroarenes with a strongly electron-withdrawing group at the para position.
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs
Wang, Ben B.,Maghami, Nima,Goodlin, Vanessa L.,Smith, Paul J.
, p. 3221 - 3226 (2007/10/03)
Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessa
Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action
Razavi, Hossein,Palaninathan, Satheesh K.,Powers, Evan T.,Wiseman, R. Luke,Purkey, Hans E.,Mohamedmohaideen, Nilofar N.,Deechongkit, Songpon,Chiang, Kyle P.,Dendle, Maria T. A.,Sacchettini, James C.,Kelly, Jeffery W.
, p. 2758 - 2761 (2007/10/03)
Benzoxazoles pevent misfolding: Benzoxazole-based inhibitors of transthyretin (TTR) amyloid fibril formation are among the most effective found to date. They stabilize TTR against both acid-mediated misfolding and urea denaturation by raising the activati
Benzamide analogs useful as PARP (ADP-ribosyltransferase, ADPRT) DNA repair enzyme inhibitors
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, (2008/06/13)
A range of 3-oxybenzamide compounds and related quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed include 3-benzyloxybenzamides, 3-oxybenzamides in which a chain of 5 or more methylene groups terminate in a halogen atom or in a purin-9-yl moiety, certain benzoxazole-4-carboxamide compounds and certain quinazolinone compounds. In formula X and Y together may form a bride -X-Y- that represents the grouping (a), (b) or (c )wherein R5 is H, alkyl, aryl or aralkyl.
