1282539-01-8Relevant academic research and scientific papers
Synthesis, characterization and biological studies of some bioactive thiazolotriazole derivatives
Kumsi, Manjunatha,Poojary, Boja,Lobo, Prajwal Lourdes,Kumari, Nalilu Suchetha,Chullikana, Anoop
, p. 1509 - 1515 (2011/02/28)
The key precursor rac-2-(4-isobutylphenyl)ethyl-1,2,4-triazole-5-thione (3) was synthesized in good yield from Ibuprofen (1). One-pot three-component reactions of 3 with 5-aryl-furan-2-carboxaldehydes/substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate afforded substituted thiazolo[3,2-b][1,2, 4]triazole derivatives 4 and 5. The structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. The compounds were tested for their in-vitro antimicrobial activities.
