128293-65-2Relevant articles and documents
Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach
Fallows, Andrew J.,Singh, Ishwar,Dondi, Ruggero,Cullis, Paul M.,Burley, Glenn A.
, p. 4654 - 4657 (2014)
Two advances in the synthesis of hairpin pyrrole-imidazole polyamides (PAs) are described. First, the application of a convergent synthetic strategy is shown, involving the Boc-based solid phase synthesis of a C-terminal fragment and the solution phase synthesis of the N-terminal fragment. Second a new hybrid resin is developed that allows for the preparation of hairpin PAs lacking a C-terminal β-alanine tail. Both methods are compatible with a range of coupling reagents and provide a facile, modular route to prepare PA libraries in high yield and crude purity.
