128333-14-2

Upstream product

• 68734-79-2 methyl 2-methyl-2-(phenylsulfanyl)propionate 
• 60100-19-8 4-methoxybenzocyclobutene-1-carboxylic acid 
• 56437-05-9 1-cyano-4-methoxybenzocyclobutane 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 128333-21-1 1,2-Dihydro-4-methoxy-1-(3-methyl-3-phenylthiobut-1-en-2-yl)benzocyclobutene 
• 23981-80-8 naproxen 
• 27602-75-1 2-(6-methoxy-2-naphthyl)propanal 
• 37414-52-1 2-(6-methoxy-2-naphthyl)-propyl alcohol 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 

Relevant academic research and scientific papers

Synthesis of 2,6-Disubstituted Dihydronaphthalenes and Naphthalenes by Electrocyclic Reaction of o-Quinodimethane. A Synthesis of (+/-)-Naproxen

A survey of the electrocyclic reactions of o-quinodimethanes generated in situ by the thermolysis of dihydrobenzocyclobutenes with a variety of olefinic substituents at C-1 is reported.These reactions provide convenient access to the 2,6-disubstituted dihydronaphthalenes (11) and the naphthalenes (12).Thermolysis of the benzocyclobutenes (10) at 180 deg C in the presence of manganese dioxide affords in good yields the 2,6-di- and 2,3,6-tri-substituted naphthalenes (12) and (16).The naphthalenes (12b,f,h) thus obtained were easily converted into (+/-)-naproxen (5).