68734-79-2

Upstream product

• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 66303-47-7 (2-Chloro-2-ethoxy-ethylsulfanyl)-benzene 
• 547-63-7 Methyl isobutyrate 
• 882-33-7 diphenyldisulfane 
• 6065-54-9 dimethyl dimethylmalonate 
• 2110-78-3 methyl 2-hydroxy-2-methylpropionate 
• 108-98-5 thiophenol 
• 17277-58-6 methyl (phenylsulfanyl)acetate 
• 74-88-4 methyl iodide 
• 931-59-9 benzenesulfenyl chloride 
• 80-62-6 methacrylic acid methyl ester 
• 67-56-1 methanol 
• 5219-64-7 2-methyl-2-(phenylthio)propanoic acid 
• 89113-95-1 (2R,3S)-2-Chloro-3-phenylsulfanyl-tetrahydro-pyran 

Downstream Products

• 128333-14-2 1,2-Dihydro-4-methoxybenzocyclobuten-1-yl 2-phenylthiopropan-2-yl ketone 
• 5219-64-7 2-methyl-2-(phenylthio)propanoic acid 
• 66164-89-4 2-methyl-2-(phenylsulfanyl)-1-propanol 
• 128333-21-1 1,2-Dihydro-4-methoxy-1-(3-methyl-3-phenylthiobut-1-en-2-yl)benzocyclobutene 

Relevant academic research and scientific papers

Generation and reactions of thiirenium ions by the Cation Pool method

Thiirenium ions generated and accumulated by low-temperature electrochemical oxidation of disulfides in the presence of alkynes were successfully observed by low-temperature NMR, Raman, and mass spectroscopies and were found to be stable at temperatures below -40 °C. The thiirenium ions showed ambident reactivity toward subsequently added nucleophiles to give either disubstituted alkenes or alkynes depending on the nature of the nucleophiles.

A new type of oxidation-reduction condensation by the combined use of phenyl diphenylphosphinite and oxidant

A new type of oxidation-reduction condensation of alcohols with sulfur, nitrogen, and oxygen nucleophiles by the combined use of phenyl diphenylphosphinite (PhOPPh2) and oxidants such as azides or diethyl azodicarboxylate (DEAD) are described. In these reactions, chiral secondary and tertiary alcohols are converted into the corresponding chiral sulfides, azides, esters and ethers under mild and neutral conditions with almost complete inversion of stereochemical configuration.

Conversion of alcohols to alkyl aryl sulfides by a new type of oxidation-reduction condensation using phenyl diphenylphosphinite

Preparation of alkyl aryl sulfides from alcohols and arenethiols such as 2-sulfanyl-1,3-benzothiazole (BtzSH) is described by a new type of oxidation-reduction condensation using phenyl diphenylphosphinite (PhOPPh 2) and benzoquinone derivatives or azide compounds. This reaction proceeds under mild and neutral conditions and is applicable to the thioetherification of various alcohols in which the chiral secondary and tertiary alcohols are converted into the corresponding chiral sulfides with almost complete inversion of configuration.

Amido compounds and their use as pharmaceuticals

The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

2-Methylprop anamides and their use as pharmaceuticals

The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

Cobalt catalysed hydro-sulfenylation of Michael acceptors

The reaction of certain types of Michael accepters, limited to those having methylene groups, with a mixture of diphenyl disulfide and phenyl silane, under the influence of 10% of the cobalt catalyst, Co(eobe) 3, results in the formation of hydro-sulfenylated products, such as α-phenylthio carbonyl compounds, in moderate to good yields. The process involves intermediates having radical character, judging by the 5-exo-trig cyclisation product 21 observed in the reaction of α,β-unsaturated ester 20 having a suitable unsaturated side-chain.

A simple synthetic route to 3-phenoxybenzyl 2-methyl-2-(p-substituted phenoxy and thiophenoxy/naphthoxy)propyl ethers, structurally related to ethofenoprox

Some 3-phenoxybenzyl 2-methyl-2-(p-substituted phenoxy and thiophenoxy/naphthoxy)propyl ethers (8), bearing close structural resemblance to the powerful insecticide MTI-500 have been synthesised by a simple route for evaluating their insecticidal properties.

Synthesis of 2,6-Disubstituted Dihydronaphthalenes and Naphthalenes by Electrocyclic Reaction of o-Quinodimethane. A Synthesis of (+/-)-Naproxen

A survey of the electrocyclic reactions of o-quinodimethanes generated in situ by the thermolysis of dihydrobenzocyclobutenes with a variety of olefinic substituents at C-1 is reported.These reactions provide convenient access to the 2,6-disubstituted dihydronaphthalenes (11) and the naphthalenes (12).Thermolysis of the benzocyclobutenes (10) at 180 deg C in the presence of manganese dioxide affords in good yields the 2,6-di- and 2,3,6-tri-substituted naphthalenes (12) and (16).The naphthalenes (12b,f,h) thus obtained were easily converted into (+/-)-naproxen (5).