1283571-16-3

Upstream product

• 98-88-4 benzoyl chloride 
• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 66774-70-7 (8S,20S)-des-A,B-8-benzoyloxy-20-(hydroxymethyl)-pregnane 
• 66774-71-8 Benzoic acid (1R,3aR,4S,7aR)-7a-methyl-1-((S)-1-methyl-2-oxo-ethyl)-octahydro-inden-4-yl ester 
• 145354-28-5 (20R)-des-A,B-8β-(benzoyloxy)-23,24-dinorcholane-22-ol 
• 67883-18-5 (3-Hydroxy-3-methylbutyl)triphenylphosphoniumbromid 
• 115527-12-3 (20R)-des-A,B-8β-(benzoyloxy)-23,24-dinorcholan-22-al 

Downstream Products

• 1283571-18-5 (8S,20S)-des-A,B-8-benzoyloxy-20-[4'-(tertbutyldimethylsilyloxy)-4'-methyl-pent-(1'E)-en-yl]-pregnane 
• 1283571-24-3 (20R)-1α-[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(tert-butyldimethyl-silyl)oxy]-19-nor-22(E)-ene-vitamin D3 tert-butyldimethylsilyl ether 

Relevant academic research and scientific papers

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D 3 compounds selectively active on intestine

Six new analogs of 2-methylene-19-nor-1α,25-dihydroxyvitamin D 3, 6-7 and 8a,b-9a,b, have been synthesized. All compounds are characterized by a trans double bond located in the side chain between C-22 and C-23. While compounds 6 and 7 possess

(20S,22E)-2-METHYLENE-19-NOR-22-ENE-1&α,25-DIHYDROXYVITAMIN D3 ANALOGS

This invention discloses (20S.22E)-2-mcthylenc-19-nor-22-enc-1α,25- dihydroxyvitamin D3 analogs, and specifically(20S,22E)-2 -methylene- 19-nor-22-ene- 1 α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhib