128396-36-1Relevant academic research and scientific papers
Synthesis and biological evaluation of substituted quinolines: Potential treatment of protozoal and retroviral co-infections
Fakhfakh, Mohammed A.,Fournet, Alain,Prina, Eric,Mouscadet, Jean-Francois,Franck, Xavier,Hocquemiller, Reynald,Figadere, Bruno
, p. 5013 - 5023 (2003)
We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure-activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections.
Preparation of quinolines substituted at the 2 or 3 position by an alkenyl or alkynyl chain
Fakhfakh, Mohamed A.,Franck, Xavier,Fournet, Alian,Hocquemiller, Reynald,Figadere, Bruno
, p. 2863 - 2875 (2002)
Quinolines substituted by a functionalized alkenyl or an alkynyl chain, either at the 2 or 3 position, were efficiently synthesized from 2-quinaldehyde and 3-bromoquinoline, respectively.
Manganese-Catalyzed Direct Olefination of Methyl-Substituted Heteroarenes with Primary Alcohols
Barman, Milan K.,Waiba, Satyadeep,Maji, Biplab
supporting information, p. 9126 - 9130 (2018/07/25)
Herein, we present the first catalytic direct olefination of methyl-substituted heteroarenes with primary alcohols through an acceptorless dehydrogenative coupling. The reaction is catalyzed by a complex of the earth-abundant transition metal manganese that is stabilized by a bench-stable NNN pincer ligand derived from 2-hydrazinylpyridine. The reaction is environmentally benign, producing only hydrogen and water as byproducts. A large number of E-disubstituted olefins were selectively obtained with high efficiency.
A concise and efficient synthesis of tetrahydroquinoline alkaloids using the phase transfer mediated Wittig olefination reaction
Diaz-Mu?oz, Gaspar,Isidorio, Raquel Geralda,Miranda, Izabel Luzia,de Souza Dias, Gabriel Nunes,Diaz, Marisa Alves Nogueira
, p. 3311 - 3315 (2017/07/27)
The present study describes the total synthesis of 1,2,3,4-tetrahydroquinoline alkaloids (±)-galipinine, (±)-cuspareine, (±)-galipeine and (±)-angustureine, in three steps and high yields (78%, 76%, 74%, and 66%, respectively) from common aldehyde and the ylide respectives. The key step of this approach is based on an unusual Wittig reaction by using the phase transfer medium (aq. NaOH/CH2Cl2 1:1 or t-BuOK/t-BuOH/CH2Cl2 1:1), affording olefinic intermediates in high yields.
Lanthanum Pentafluorobenzoate-Catalyzed Aerobic Oxidative Olefination of Benzylamines with 2-Methylquinoline through Deamination and C-H Bond Functionalization
Mao, Dan,Zhu, Xiaoyan,Hong, Gang,Wu, Shengying,Wang, Limin
supporting information, p. 2481 - 2484 (2016/10/21)
An efficient direct aerobic oxidative olefination of the methyl groups of 2-methylquinolines with benzylamines in the presence of a rare-earth-metal Lewis acid catalyst to give 2-styrylquinolines was successfully developed. Preliminary mechanistic studies revealed that the oxidative olefination reaction proceeds through a Lewis acid-catalyzed 2-methylquinoline-aldehyde condensation and an amine-aldehyde condensation.
