1284260-28-1

Basic information

• Product Name: C₂₆H₃₄Cl₂N₆O₅
• Synonyms: C₂₆H₃₄Cl₂N₆O₅
• CAS NO: 1284260-28-1
• Molecular Weight: 581.499
• Mol File: 1284260-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₄Cl₂N₆O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₄Cl₂N₆O₅(1284260-28-1)
• EPA Substance Registry System: C₂₆H₃₄Cl₂N₆O₅(1284260-28-1)

Safety Data

• Hazardous Substances Data: 1284260-28-1(Hazardous Substances Data)

Upstream product

• 58-54-8 ethacrynic acid 
• 1284258-81-6 1-{4-[(4-aminobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one 
• 305-84-0 carnosine 
• 1284258-80-5 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one 

Relevant articles and documents

Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries

The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid butyl amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs were found to have a good anti-tumor activity comparable to cisplatin.