128495-29-4Relevant academic research and scientific papers
Efficient preparation of 1,4,8-trimethylcyclam and its conversion into a thioalkyl-pendant pentadentate chelate
Halfen, Jason A.,Young Jr., Victor G.
, p. 2894 - 2895 (2003)
A facile synthesis of 1,4,8-trimethylcyclam and a thioalkyl-pendant derivative are reported, and the X-ray crystal structure of a nickel(II) complex illustrates structural consequences of appending the thiolate donor onto the macrocycle.
Achieving Reversible Sensing of Nitroxyl by Tuning the Ligand Environment of Azamacrocyclic Copper(II) Complexes
Kim, Sunghee,Minier, Mikael A.,Loas, Andrei,Becker, Sabine,Wang, Fang,Lippard, Stephen J.
, p. 1804 - 1807 (2016)
To elucidate the factors that impart selectivity for nitroxyl (HNO) over nitric oxide (NO), thiols, and H2S in metal-based fluorescent probes, we investigated five Cu(II)-cyclam (14-N4) derivatives. Upon exposure to NO gas at pH 7, n
Sulfur-containing small-molecule compound and application thereof
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Paragraph 0014, (2019/09/14)
The invention discloses a sulfur-containing small-molecule compound and an application thereof. The sulfur-containing small-molecule compound is prepared from azacycloalkane and p-toluenesulfonyl chloride as raw materials by using a simple preparation pro
1-(4-Tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane (Tscyclam): A versatile ligand for nickel(II) and nickel(III) cations
Calligaris, Mario,Carugo, Oliviero,Crippa, Giuseppe,De Santis, Giancarlo,Di Casa, Michela,Fabbrizzi, Luigi,Poggi, Antonio,Seghi, Barbara
, p. 2964 - 2970 (2008/10/08)
1-(4-Tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane (Tscyclam, 3) forms complexes with NiII of stoichiometry: Ni(Tscyclam)X2·2H2O (X = Cl, ClO4). The crystal structure has been determined for the chloride complex salt, which indicates that the complex is better described by the formula [Ni(Tscyclam)(H2O)2]Cl2. The salt crystallizes in the monoclinic space group P21/n, with a = 13.030 (5) A?, b = 7.859 (3) A?, c = 22.640 (9) A?, β = 93.17 (3)°, V = 2315 (2) A?3, and Z = 4. The structure was solved by using 3062 unique reflections with I0 > 3σ(I0). Anisotropic least squares refinement gave R = 0.11. The tetraaza macrocycle is folded and the two water molecules occupy two cis positions of a distorted octahedron. Average distance for the NiII(high spin)-N(amine) bonds is 2.08 (2) A?, whereas the NiII(high spin)-N(amide) distance is 2.36 (1) A?. The [Ni(Tscyclam)(H2O)2]2+ chromophore keeps intact its stereochemical arrangement on dissolution both in water and in noncoordinating solvents (e.g. CH2Cl2). Tscyclam has been used as a carrier for the transport of NiII across a bulk liquid membrane, displaying a much greater efficiency than the lipophilic version of cyclam (N-cetylcyclam, 2). The aqueous [NiII(Tscyclam)(H2O)2]2+ complex, in the presence of Cl- ions, is oxidized by persulfate to give the species [NiIII(Tscyclam)Cl2]+, in which two equivalent chloride ions lie on the z axis and the tetraaza macrocycle is coplanarly chelated, as shown by the ESR of the frozen solution. Coplanar coordination of Tscyclam is now allowed due to the smaller dimensions of the NiIII metal center compared to high-spin NiII. The NiIII/NiII redox change could not be characterized through voltammetric investigations at the platinum electrode, but it was possible, through chemical evidence, to locate the potential for the [NiIII(Tscyclam)Cl2]+/[Ni II(Tscyclam)(H2O)2]2+ couple at an especially low value (III(cyclam)Cl2]+/[Ni II(cyclam)]2+ redox couple.
