406939-92-2Relevant articles and documents
Dramatically enhanced carbon acidity of the nitrobenzyl fragment in a nickel(II) scorpionate complex
Boiocchi, Massimo,Fabbrizzi, Luigi,Foti, Francesco,Monzani, Enrico,Poggi, Antonio
, p. 3417 - 3420 (2005)
(Chemical Equation Presented) The -CH2- group of the 2-nitrobenzyl pendant arm of the scorpionate complex I deprotonates in basic aqueous solution (pKa = 10.6), due to the coordination of the nitronate group to the nickel(II) center.
Plerixafor crystal form D, plerixafor intermediate crystal form S and preparation methods and application thereof
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Paragraph 0055-0056, (2021/05/29)
The invention relates to a plerixafor crystal form D, a plerixafor intermediate crystal form S and preparation methods and application thereof. By preparing the plerixafor crystal form D, a plerixafor raw material medicine which is easier to store is obtained, the plerixafor crystallization process is simplified, and the plerixafor crystal form D is suitable for large-scale production. By preparing the plerixafor key intermediate crystal form S, the purification process of the intermediate is simplified, and the purity of the prepared plerixafor raw material medicine is improved.
Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression
Brickute, Diana,Braga, Marta,Kaliszczak, Maciej A.,Barnes, Chris,Lau, Doreen,Carroll, Laurence,Stevens, Elizabeth,Trousil, Sebastian,Alam, Israt S.,Nguyen, Quang-Dé,Aboagye, Eric O.
, p. 2106 - 2117 (2019/05/15)
In humans, C-X-C chemokine receptor type 4 (CXCR4) is a protein that is encoded by the CXCR4 gene and binds the ligand CXCL12 (also known as SDF-1). The CXCR4-CXCL12 interaction in cancer elicits biological activities that result in tumor progression and