128550-06-1

Basic information

• Product Name: (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane
• Synonyms: (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane
• CAS NO: 128550-06-1
• Molecular Weight: 659.908
• Mol File: 128550-06-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane(CAS DataBase Reference)
• NIST Chemistry Reference: (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane(128550-06-1)
• EPA Substance Registry System: (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane(128550-06-1)

Safety Data

• Hazardous Substances Data: 128550-06-1(Hazardous Substances Data)

Usage

General Description

The chemical "(N^1,N^4,N^9,N^13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane" is a compound with a complex structure. It contains four tert-butoxycarbonyl groups, as well as multiple amino groups. (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane is often used as a protecting group in organic synthesis, as the tert-butoxycarbonyl groups can be selectively removed under mild conditions to reveal the amino groups. The presence of the multiple amino groups also makes this compound useful in the formation of peptide bonds. Additionally, the triazahexadecane backbone provides flexibility and rigidity to the molecule, making it potentially valuable in the design of new drugs or materials.

Upstream product

• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 201984-66-9 1-trifluoroacetyl-5,10,14-tris-Boc-spermine 
• 202145-88-8 N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2,2,2-trifluoroacetamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 71-44-3 Spermine 
• 201984-76-1 N¹,N⁵,N¹⁰-tri-tert-butoxycarbonyl-N¹⁸-benzyloxycarbonyl-1,5,10,14,18-pentaazaoctadecane 
• 128550-04-9 20-cyano-2,2-dimethyl-4-oxo-3-oxa-5,9,14,18-tetraazaeicosane-9,14-dicarboxylic acid bis(1,1-dimethylethyl) ester 
• 114459-62-0 tri-Boc-spermine 
• 196704-28-6 (3-Benzyloxycarbonylamino-propyl)-[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propyl]-carbamic acid tert-butyl ester 
• 128550-05-0 2-(2-cyanoethyl)-6,11-bis<(1,1-dimethylethoxy)carbonyl>-2,6,11,15-tetraazahexadecanedioic acid bis(1,1-dimethylethyl) ester 
• 1208364-62-8 [3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylaminopropyl)-amino]-butyl}-amino)-propyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamic acid tertiary-butyl ester 
• 65564-05-8 3-[(benzyloxycarbonyl)amino]propanal 
• 128550-03-8 2-(2-cyanoethyl)-7-<(1,1-dimethylethoxy)carbonyl>-2,7,11-triazadodecanedioic acid bis(1,1-dimethylethyl) ester 
• 128550-02-7 16-cyano-2,2-dimethyl-3-oxa-4-oxo-5,9,14-triazahexadecane 

Downstream Products

• 128550-15-2 1-<4-(methoxymethoxy)phenyl>-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester 
• 128550-17-4 1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester 
• 133416-41-8 1-<2,5-bis(methoxymethoxy)phenyl>-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester 
• 128550-18-5 1-<2,5-bis(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester 
• 128549-98-4 N-(20-amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-4-hydroxybenzamide 
• 128549-99-5 N-(20-amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-2,5-dihydroxybenzamide 
• 128549-97-3 N-(20-amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-4-hydroxy-1H-indole-3-acetamide 
• 1208364-63-9 C₆₃H₉₀N₆O₁₈ 
• 930265-72-8 [3-({3-[bis-(2-cyano-ethyl)-amino]-propyl}-tert-butoxycarbonyl-amino)-propyl]-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-carbamic acid tert-butyl ester 
• 128550-26-5 [3-(tert-Butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propyl]-[3-(2-cyano-ethylamino)-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes

Polyamine amides are useful in gene delivery as synthetic (non-viral) vectors or mimics of polycationic histones. The application of a homologation strategy, based upon reductive alkylation, allows unsymmetrical polyamine amides to be prepared in good yie

NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS

The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C1-4alkyI, - A represents CO(CH2)n or CONH(CH2)n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.

Polycationic sulfonamides for the sequestration of endotoxin

Lipopolysaccharides (LPS) play a key role in the pathogenesis of septic shock, a major cause of mortality in the critically ill patient. We had previously shown that monoacylated polyamine compounds specifically bind to and neutralize the activity of LPS with high in vitro potency and afford complete protection in a murine model of endotoxic shock. Fatty acid amides of polyamines may be rapidly cleared from systemic circulation due to their susceptibility to nonspecific serum amidases and, thus, would be predicted to have a short duration of action. In a systematic effort to increase the likelihood of better bioavailability properties together with structural modifications that may result in gains in activity, we now report structure-activity relationships pertaining to endotoxin-binding and -neutralizing activities of homologated polyamine sulfonamides.