1285560-10-2

Upstream product

• 100-46-9 benzylamine 
• 64984-60-7 4-oxo-4-[(phenylmethyl)amino]butanoic acid 
• 2142-06-5 1-(phenylmethyl)-2,5-pyrrolidinedione 
• 83-34-1 3-Methylindole 
• 41194-02-9 1-benzyl-5-hydroxypyrrolidin-2-one 

Relevant academic research and scientific papers

Synthesis and spectral features of new 1-alkyl-5-(indol-2(3)-yl)pyrrolidin- 2-ones

The mass spectrometric behavior of 1-alkyl-5-(1H-indol-2-yl)pyrrolidin-2- ones and 1-alkyl-5-(1H-indol-3-yl)pyrrolidin-2-ones was studied and the fragmentation of these compounds was established. The product of N-methylindole reaction with 1-benzyl-5-hydroxypyrrolidin-2-one was shown to be 1-benzyl-5-(1-methylindol-3-yl)pyrrolidin-2-one.

Regioselective synthesis of 1-alkyl-5-(indol-3-yl- and -2-yl)pyrrolidin-2- ones from available reagents

The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones.