1285572-51-1

Usage

Uses

Dotinurad is a useful drug for treating hyperuricemia and gout.

Upstream product

• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 
• 4433-53-8 2,3-dihydro-1,1-dioxobenzothiazole 
• 59595-92-5 chlorure de dichloro-3,5 hydroxy-4 benzoyle 
• 1285572-54-4 (3,5-dichloro-4-hydroxyphenyl)-(3-(2H)-benzothiazolyl)methanone 
• 137-07-5 2-amino-benzenethiol 
• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 4433-52-7 2,3-dihydro-benzothiazole 
• 1285573-44-5 3-(3,5-dichloro-4-methoxybenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole 
• 1285573-42-3 3-(3,5-dichloro-4-methoxybenzoyl)-1,2-dihydro-3H-1,3-benzothiazole 
• 29568-76-1 3,5-Dichloro-4-methoxybenzoyl chloride 

Relevant academic research and scientific papers

Preparation method of dotinurad

The invention discloses a preparation method of dotinurad. According to the preparation method, condensation, cyclization, oxidation and other reactions are conducted in sequence, with 2-aminobenzenemercaptan used as an initial raw material, so the target product dotinurad is obtained. The preparation method has the advantages of easily available raw materials, rapidness, convenience, economic performance, environmental protection performance and suitability for large-scale industrial production.

Synthetic method of Dotinurad

The invention discloses a synthesis method of Dotinurad, which is characterized in that 2, 3-dihydrobenzothiazole is used as an initial raw material, and the target product Dotinuradis conveniently synthesized through oxidation and condensation reactions. The preparation process has the advantages of easily available raw materials, rapidness, convenience, economy, environmental protection and suitability for large-scale industrial production.

Preparation method of dotinurad

The invention discloses a preparation method of dotinurad. The preparation method comprises the following steps: with 2-aminophenylmercaptan as an initial raw material, sequentially carrying out acylation, cyclization of diiodomethane, oxidation and other reactions to obtain the target product dotinurad. The preparation method has the advantages of easily available raw materials, rapidness, convenience, economic performance and environmental protection performance, overcomes the use of formaldehyde in existing processes, and is suitable for large-scale industrial production.

Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity

To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a 1,1-dioxo-1,2-dihydro-

NOVEL PHENOL DERIVATIVE

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt t