128576-60-3

Upstream product

• 120230-41-3 N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester 
• 100-52-7 benzaldehyde 
• 104072-49-3 L-aspartic acid α-t-butyl β-methyl diester 

Downstream Products

• 128576-61-4 1-(tert-butyl) 4-methyl N-benzyl-N-(9-phenyl-9H-fluoren-9-yl)-L-aspartate 
• 128576-62-5 (2S,3R)-1-tert-butyl 4-methyl N-benzyl-N-(9-phenylfluoren-9-yl)-3-benzyl 
• 128576-62-5 (2S,3S)-1-tert-butyl 4-methyl N-benzyl-N-(9-phenylfluoren-9-yl)-3-benzylaspartate 
• 128576-64-7 (2S,3S) and (2S,3R)-1-tert-butyl N-(tert-butoxycarbonyl)-3-benzylaspartate 
• 128576-63-6 (2S,3S)-1-tert-butyl 4-methyl N-(tert-butoxycarbonyl)-3-benzylaspartate 
• 127605-48-5 (2S,3S)-2-Amino-3-benzyl-succinic acid 1-tert-butyl ester 4-methyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of allele-specific BET inhibitors

Developing stereoselective synthetic routes that are efficient and cost-effective allows easy access to biologically active molecules. Our previous syntheses of allele-selective bumped inhibitors of the Bromo and Extra-Terminal (BET) domain proteins, Brd2

Total Synthesis of α- and β-Amanitin

α-Amanitin and related amatoxins have been studied for more than six decades mostly by isolation from death cap mushrooms. The total synthesis, however, remained challenging due to unique structural features. α-Amanitin is a potent inhibitor of RNA polyme

Methods for synthesizing amatoxin building block and amatoxins

The invention relates to novel methods for synthesizing a synthon for γ,δ-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.

METHODS FOR SYNTHESIZING AMATOXIN BUILDING BLOCK AND AMATOXINS

The invention relates to novel methods for synthesizing a synthon for γ,δ- dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.

Stereoselective Synthesis of 2,3-Diamino Acids. 2,3-Diamino-4-phenylbutanoic Acid

The synthesis of (2S,3S)- and (2S,3R)-2,3-diamino-4-phenylbutanoic acid (1c and 3) from L-aspartic acid is described.The N-(phenylfluorenyl)-protected aspartic acid diesters 4 and 10 (α-tert-butyl, β-methyl), 18 (β-benzyl, α-tert-butyl), and 28 (β-benzyl,