128702-33-0Relevant academic research and scientific papers
4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS
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Page/Page column 113-114, (2010/02/13)
The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.
4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
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, (2008/06/13)
The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.
APPLICATION OF 4-AZIDOBENZYL GROUP TO PROTECTION OF HYDROXYL FUNCTIONS
Fukase, Koichi,Hashida, Manabu,Kusumoto, Shoichi
, p. 3557 - 3558 (2007/10/02)
The 4-azidobenzyl ether can be readily formed and cleaved either by direct oxidation with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) or by oxidation after conversion to the 4-aminobenzyl ether or the corresponding iminophosphorane derivative.In the latter two-step cleavage methods the azidobenzyl group is removed in preference to the 4-methoxybenzyl (MPM) group, whereas the MPM group can be selectively removed by the direct DDQ oxidation.
4-NITROBENZYL GROUP FOR PROTECTION OF HYDROXYL FUNCTIONS
Fukase, Koichi,Tanaka, Hideo,Torii, Sigeru,Kusumoto, Shoichi
, p. 389 - 392 (2007/10/02)
Versatile use of 4-nitrobenzyl group for protection of hydroxyl functions is described.It can be removed selectively in the presence of other benzyl-type protecting groups such as benzyl and 4-methoxybenzyl via reduction into 4-aminobenzyl group followed by electrochemical oxidation.Very clean oxidative cleavage of 4-aminobenzyl group could also be effected with 2,3-dichloro-5,6-dicyanobenzoquinone after N-acetylation.
