128753-05-9

Upstream product

• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 81113-20-4 ethyl 1-hydroxy-4-phenyl-2-naphthalenecarboxylate 
• 1206821-34-2 C₂₂H₂₇NO₄ 
• 1196876-27-3 C₂₀H₂₅NO₄ 
• 1196876-28-4 C₁₉H₂₁NO₄ 
• 1244616-34-9 C₂₀H₂₃NO₄ 
• 1244616-28-1 C₁₉H₂₁NO₃ 
• 1244616-09-8 C₁₈H₁₈ClNO₃ 
• 21139-26-4 ethyl 5-chloro-1-methyl-3-phenylindole-2-carboxylate 
• 1244616-21-4 C₁₈H₁₈BrNO₃ 
• 1244616-17-8 C₁₈H₁₈ClNO₃ 
• 1244616-13-4 C₁₈H₁₈ClNO₃ 
• 1244616-38-3 C₁₉H₂₁NO₄ 
• 67271-25-4 C₁₈H₁₉NO₃ 
• 213881-50-6 ethyl 1-methyl-3-phenyl-1H-indole-2-carboxylate 

Relevant academic research and scientific papers

Transition-metal-free approach to synthesis of indolines from N-(ortho-chloromethyl)aryl amides and iodonium ylides

A transition-metal-free method for the synthesis of indolines has been developed. In the presence of K2CO3, the cyclization reaction of N-(ortho-chloromethyl)aryl amides and iodonium ylides proceeded smoothly at room temperature in moderate to good yields.

Reaction of iodonium ylides of 1,3-dicarbonyl compounds with HF reagents

Reaction of dibenzoylmethane with (diacetoxyiodo)benzene in the presence of KOH in MeCN quantitatively gave the corresponding iodonium ylide, which was treated with a HF reagent to afford the corresponding 2-fluorinated dibenzoylmethane in 14-50% yields.

The acid-promoted reactions of phenyliodonium ylides with substituted anilines and their applications to the synthesis of indoles

The N-substituted anilines 1 react readily with phenyliodonium ylides 2 derived from 1,3-dicarbonyl compounds in the presence of a catalytic amount of BF3·Et2O, forming the C-N coupling products 3, which are precursors for the synthesis of indoles. On the basis of this result, the direct synthesis of indoles from 1 and 2 under thermal conditions and photochemical conditions was explored. The transformations could be achieved in a one-pot way under thermal conditions or in a tandem manner under photochemical conditions.