128839-29-2

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 631-61-8 ammonium acetate 
• 100-52-7 benzaldehyde 
• 126-81-8 dimedone 
• 5443-49-2 α-bromocinnamaldehyde 
• 873-95-0 1-amino-5,5-dimethylcyclohexen-3-one 
• 66894-04-0 2,3-dibromo-3-phenyl propanal 
• 113519-39-4 2-{[2-(N',N'-Dimethyl-hydrazino)-4,4-dimethyl-6-oxo-cyclohex-1-enyl]-phenyl-methyl}-malonic acid dimethyl ester 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 69948-54-5 3-(2,2-dimethylhydrazino)-5,5-dimethylcyclohex-2-en-1-one 
• 113519-47-4 1-Dimethylamino-7,7-dimethyl-2,5-dioxo-4-phenyl-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Ionic liquid supported nanoporous silica (SBA-IL) as an efficient and heterogeneous catalyst in the domino synthesis of polyhydroquinoline derivatives

A simple, efficient, and environmentally benign protocol for the synthesis of polyhydroquinoline derivatives was developed using a bio-compatible, heterogeneous, and recoverable mesoporous ionic liquid supported nanoporous silica as a nano-catalyst. The p

One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Catalyzed by Silica-Coated Magnetic NiFe2O4 Nanoparticles-Supported H14[NaP5W30O110]

Silica-coated magnetic NiFe2O4 nanoparticles-supported H14[NaP5W30O110] (NiFe2O4@SiO2-H14[NaP5W30O110]) was succ

N-heterocyclic carbene catalyzed reactions of α-bromo-α,β- unsaturated aldehydes/α,β-dibromoaldehydes with 1,3-dinucleophilic reagents

Carbenes ring true: N-Heterocyclic carbene (NHC) catalyzed reactions of α-bromo-α,β-unsaturated aldehydes/α,β- dibromoaldehydes with 1,3-dinucleophilic reagents, such as 1,3-dicarbonyl compounds, β-enamino ketones, and β-enamino esters through umpolung processes gave functionalized 3,4-dihydropyranones and 3,4-dihydropyridinones (see scheme). The availability of the starting materials, lack of external oxidant, and usefulness of the products make this strategy attractive.

The synthesis of novel substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines without solvent under microwave irradiation

A convenient synthetic method for substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines is described. Heating Meldrum's acid, dimedone, ammonium acetate and different aromatic aldehydes without a solvent in a microwave irradiation for 2-5 minutes affords 4 in 72-86% yield. The structure of these compounds has been thoroughly studied by x-ray crystallographic analysis.

A joint experimental and theoretical structural study of novel substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines

A series of substituted 2,5-dioxo-l,2,3,4,5,6,7,8-octahydroquinolines have been synthesised from Meldrum's acid and dimedone in the presence of different aldehydes by following an approach similar to the one developed by Hantzsch. The structure of these c

ASYMMETRIC MICHAEL ADDITION/LACTAMIZATION VIA SAMP-/RAMP-HYDRAZONES ENANTIOSELECTIVE SYNTHESIS OF SUBSTITUTED TETRAHYDRO-2,5(1H,3H)-QUINOLINEDIONES

An efficient and highly diastereo- and enantioselective annulation of cyclic 1.3-diketones to tetrahydro-quinolinediones of type 4 and 5 in good overall yields is described.The key step is the Michael addition of the corresponding lithiated SAMP-/RAMP-hydrazones to arylidenemalonates followed by lactamization with virtually complete asymmetric induction (de,ee98percent).