1289154-41-1

Upstream product

• 63093-41-4 ethyl 4-pentynoate 
• 696-62-8 para-iodoanisole 
• 6089-09-4 4-pentynoic acid 
• 1374311-41-7 N-allyl-4-pentynamide 
• 729580-61-4 ethyl 5-(4-methoxylphenyl)-4-pentynoate 
• 137742-44-0 5-<4-methoxyphenyl>-4-pentynoic acid 
• 107-11-9 1-amino-2-propene 

Downstream Products

• 1289154-49-9 (E)-8-(α-acetyloxy-4'-methoxybenzylidenyl)-5-oxoindolizidine 
• 1374311-46-2 (+/-)-N-allyl-5-(4-methoxyphenylcarbonyl)-2-pyrrolidinone 
• 111975-29-2 (+/-)-tashiromine 

Relevant academic research and scientific papers

Synthesis of (±)-trans-indolizidine-8-carboxylic acid

A facile synthesis of a novel amino acid, trans-indolizidine-8-carboxylic acid, is described. Georg Thieme Verlag Stuttgart - New York.

Rhodium-Catalyzed Domino Hydroformylation/Double-Cyclization Reaction of Arylacetylenecarboxamides: Diastereoselectivity Studies and Application in the Synthesis of 1-Azabicyclo[x.y.0]alkanes

A domino method for the rapid syntheses of 1-azabicyclo[x.y.0]alkane scaffolds, such as indolizidines, quinolizidines, decahydropyridoazepines, and their derivatives, has been developed. This strategy involved a rhodium-catalyzed hydroformylation of allyl

Application of the intramolecular PIFA-mediated amidation of alkynes to the synthesis of substituted indolizidinones

The construction of the title compounds has been achieved from properly substituted linear alkynylamides through the suitable combination of two key cyclization steps. First, an intramolecular PIFA-mediated alkyne amidation protocol leads to the creation

Alkyne-mediated domino hydroformylation/double cyclization: Mechanistic insight and synthesis of (±)-tashiromine

A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.