129050-20-0

Basic information

• Product Name: 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
• Synonyms: 6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID;6-fluoro-3,4-hidro-2H-1-Benzopyran-2-carboxylic acid;6-Fluoro-3,4-Dihydro-2(1H)-Benzopyrancarboxylic Acid;6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-CARBOXYLOC ACID
• CAS NO: 129050-20-0
• Molecular Formula: C10H9FO3
• Molecular Weight: 196.18
• Mol File: 129050-20-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 358.037 °C at 760 mmHg
• Flash Point: 170.335 °C
• Appearance: /
• Density: 1.365 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid(129050-20-0)
• EPA Substance Registry System: 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid(129050-20-0)

Safety Data

• Hazardous Substances Data: 129050-20-0(Hazardous Substances Data)

Usage

General Description

6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid, also known as FDC, is a chemical compound with a molecular formula C10H9FO3. It is a synthetic derivative of the natural flavonoid, dihydroquercetin, and it has been studied for its potential anti-inflammatory and antioxidant properties. FDC has been proposed as a potential treatment for inflammatory diseases and oxidative stress-related conditions. Its structure contains a fluorine atom attached to a benzopyran ring, which may contribute to its biological activity. Further research is needed to fully understand the therapeutic potential and mechanisms of action of FDC.

InChI:InChI=1/C10H9FO3/c11-7-2-4-8-6(5-7)1-3-9(14-8)10(12)13/h2,4-5,9H,1,3H2,(H,12,13)

Upstream product

• 1219915-01-1 (S)-methyl 6-fluorochroman-2-carboxylate 
• 129050-25-5 (R)-methyl 6-fluorochroman-2-carboxylate 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 
• 371-41-5 4-Fluorophenol 
• 874649-82-8 (-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate 
• 134102-10-6 methyl 6-fluoro-4-oxo-3,4-dihydro-2H-chroman-2-carboxylate 
• 99199-59-4 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid 
• 312314-37-7 2-(benzyloxy)-5-fluorobenzaldehyde 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 

Downstream Products

• 155427-30-8 (+)-(S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carbonyl chloride 
• 878208-57-2 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide 
• 1219915-04-4 (R)-6-fluoro-2-(oxiran-2-yl)chroman 
• 943126-72-5 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one 
• 129050-27-7 (R*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol 
• 793669-26-8 [R*(S*)]-6-fluoro-3,4-dihydro-2-oxiran-2-yl-2H-benzopyran 
• 152520-56-4 nebivolol hydrochloride 
• 129050-27-7 (S*,R*)-(+/-)-α-[(benzylamino)methyl]-(6-fluoro-2-chromanyl)methanol 
• 793669-26-8 [R*(R*)]-6-fluoro-3,4-dihydro-2-oxiran-2-yl-2H-benzopyran 
• 897661-66-4 2-amino-1-(-6-fluoro-2-chromanyl) ethanol 
• 793669-26-8 [1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 793669-26-8 [1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 409346-73-2 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde 
• 99199-62-9 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol 

Relevant articles and documents

Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and anti-oxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4- oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target–cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

Preparation method of chromanone 2-carboxylic acid or chroman 2-carboxylic acid derivatives

The present invention relates to a chromanone-2-carboxylic acid derivative and a chroman-2-carboxylic acid derivative which can be used as an intermediate for effective medicinal components currently available in the market, and to preparation methods the

An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates

Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2′-hydroxy)phenylbutanoates derived from l-malic acid.