129098-56-2

Usage

Uses

Used in Organic Synthesis:
(R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE is used as a key intermediate in the synthesis of various organic compounds. Its unique structure, which includes a bromophenyl group and an epoxide ring, allows for a wide range of reactions and functional group transformations, making it a valuable building block in the development of new molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE is used as a starting material for the development of new drugs. Its chiral nature and reactive functional groups make it an attractive candidate for the creation of novel therapeutic agents. Researchers are exploring its potential in the design and synthesis of molecules with specific biological activities, such as those targeting various diseases or conditions.
Used in Chemical Research:
(R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE is also utilized in chemical research to study the reactivity and properties of epoxides and bromophenyl groups. (R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE serves as a model system for understanding the fundamental chemical reactions and mechanisms that occur in the presence of these functional groups, which can be applied to the development of new synthetic methods and strategies.

Upstream product

• 124-38-9 carbon dioxide 
• 2212-06-8 2-((4-bromophenoxy)methyl)oxirane 
• 67843-74-7 (S)-epichlorohydrin 
• 106-41-2 4-bromo-phenol 

Relevant academic research and scientific papers

Chiral Macrocyclic Organocatalysts for Kinetic Resolution of Disubstituted Epoxides with Carbon Dioxide

Among chiral macrocycles 1 synthesized, 1m with the 3,5-bis(trifluoromethyl)phenylethynyl group was the best organocatalyst for the enantioselective synthesis of cyclic carbonates from disubstituted or monosubstituted epoxides and CO2. The X-ray crystal structure of 1m revealed a well-defined chiral cavity with multiple hydrogen-bonding sites that is suitable for the enantioselective activation of epoxides. A catalytic cycle proposed was supported by DFT calculations.

CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulators which may be used as medicaments

PHENYL-(AZA)CYCLOALKYL CARBOXYLIC ACID GPR120 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Bacillus alcalophilus MTCC10234 catalyzed enantioselective kinetic resolution of aryl glycidyl ethers

The phenyl glycidyl ether derivatives have been kinetically resolved with the growing cells of Bacillus alcalophilus MTCC10234 yielding (S)-epoxides with up to >99% ee and (R)-diols with up to 89% ee. The enantiomeric ratio (E) of up to 67 has been obtained for biohydrolysis process. The effect of different substituents of phenyl glycidyl ether on the biocatalytic efficiency of B. alcalophilus MTCC10234 showed preference for methyl- and chloro-substituted aryl glycidyl ether derivatives whereas nitro-derivatives were transformed at a slower rate. 2,6-Dimethylphenyl glycidyl ether which contains a bulky aryl group having methyl group on both the ortho positions was resolved with an E=39.

Enantioselective incorporation of carbon dioxide into epoxides catalyzed by optically active cobalt(II) complexes

The enantioselective chemical fixation of CO2 into an epoxide was developed using an optically active ketoimi-natocobalt(II) complex as a chiral Lewis acid. In the presence of a catalytic amount of the cobalt complex and amine base, enantioselective CO2 fixation with an epoxide proceeded with kinetic resolution to afford the corresponding carbonate along with unreacted epoxide, both of which were optically active. To improve their enantioselectivities, the ligand structures of the cobalt complexes and amine bases were examined. Thus, the optimized catalytic system was successfully applied to various epoxides to obtain the corresponding optically active cyclic carbonates and to recover epoxides with good-to-high enantioselectivities.