129108-75-4Relevant academic research and scientific papers
New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation
De Vita, Daniela,Pandolfi, Fabiana,Ornano, Luigi,Feroci, Marta,Chiarotto, Isabella,Sileno, Ilaria,Pepi, Federico,Costi, Roberta,Di Santo, Roberto,Scipione, Luigi
, p. 106 - 113 (2016)
A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE). The most active compounds 4 and 8, showed 85 and 69% of inhibition at 50 μM, respectively
Cobalt-Catalyzed Remote Hydroboration of Alkenyl Amines
Lei, Yaqin,Huang, Jiaxin,Zhao, Wanxiang
, p. 7797 - 7802 (2021/10/20)
We here present a generally applicable cobalt-catalyzed remote hydroboration of alkenyl amines, providing a practical strategy for the preparation of borylamines and aminoalcohols. This method shows broad substrate scope and good functional group tolerance, tolerating a series of alkenyl amines, including alkyl-alkyl amines, alkyl-aryl amines, aryl-aryl amines, and amides. Of note, this protocol is also compatible with a variety of natural products and drug derivatives. Preliminary mechanistic studies suggest that this transformation involves an iterative chain walking and hydroboration sequence.
Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
-
, (2009/01/20)
The Invention relates to compounds having an antiparasitic activity, and to their use as a drug, in particular as a drug for the prevention and/or treatment of parasitic diseases caused by apicomplexans. The invention also relates to pharmaceutical compositions containing those compounds.
