129141-70-4

Upstream product

• 129141-66-8 2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine 
• 814-68-6 acryloyl chloride 
• 824-94-2 p-methoxybenzyl chloride 
• 2797-17-3 2',3'-O-isopropylidene-5-fluorouridine 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 129141-73-7 5'-O-acryloyl-3-(4-methoxybenzyl)-5-fluorouridine 

Relevant academic research and scientific papers

A synthesis of 5'-O-acryloyl-5-fluorouridine by use of p-methoxybenzyl group as an N3-imide protecting group of 5-fluorouridine

5'-O-Acryloyl-5-fluorouridine was preparedd by use of p-methoxybenzyl (PMB) group as an N3-imide protecting group of 5-fluorouridine. PMB group was introduced chemoselectively by use of N,N-diisopropylethylamine or DBU as a base. A new deprotection method was developed by means of AlCl3-anisole system at room temperature.

p-Methoxybenzyl as a New N3-Imide Protecting Group of 5-Fluorouridine and Its Application to the Synthesis of 5'-O-Acryloyl-5-fluorouridine

5'-O-Acryloyl-5-fluorouridine was prepared by use of p-methoxybenzyl (PMB) group as a new N3-imide protecting group of 5-fluorouridine.A chemoselective method for protection has been developed by use of ethyldiisopropylamine as a base and depro