129141-75-9

Upstream product

• 129141-72-6 (E)-3-Phenyl-acrylic acid (3aR,4R,6R,6aR)-6-[5-fluoro-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 129141-66-8 2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine 
• 2797-17-3 2',3'-O-isopropylidene-5-fluorouridine 
• 129141-72-6 5'-O-cinnamoyl-2',3'-O-isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine 
• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 129141-78-2 5'-O-Cinnamoyl-5-fluorouridine 
• 129141-78-2 (E)-3-Phenyl-acrylic acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

A synthesis of 5'-O-acryloyl-5-fluorouridine by use of p-methoxybenzyl group as an N3-imide protecting group of 5-fluorouridine

5'-O-Acryloyl-5-fluorouridine was preparedd by use of p-methoxybenzyl (PMB) group as an N3-imide protecting group of 5-fluorouridine. PMB group was introduced chemoselectively by use of N,N-diisopropylethylamine or DBU as a base. A new deprotection method was developed by means of AlCl3-anisole system at room temperature.

p-Methoxybenzyl as a New N3-Imide Protecting Group of 5-Fluorouridine and Its Application to the Synthesis of 5'-O-Acryloyl-5-fluorouridine

5'-O-Acryloyl-5-fluorouridine was prepared by use of p-methoxybenzyl (PMB) group as a new N3-imide protecting group of 5-fluorouridine.A chemoselective method for protection has been developed by use of ethyldiisopropylamine as a base and depro