t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate

Base Information

• Chemical Name: t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate
• CAS No.: 1292268-15-5
• Molecular Formula: C₁₉H₃₈N₄O₈
• Molecular Weight: 450.533

Synonyms:t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate

Chemical Property of t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

BocNH-PEG6-CH2CH2N3 min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: t-boc-N-amido-PEG6-azide is a azide containing crosslinking reagent with a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The reagent can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate

There total 10 articles about t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,2-dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-yl 4-methylbenzenesulfonate (1292268-14-4) → t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate (1292268-15-5)

Guidance literature:

With sodium azide; sodium iodide; In water; acetone; at 80 ℃; for 48h;

DOI:10.1002/ejoc.201001666

Reference yield: 83.0%

tert-butyl (20-amino-3,6,9,12,15,18-hexaoxaicosyl)carbamate (1091627-77-8) → t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate (1292268-15-5)

Guidance literature:

With imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate; In methanol;

DOI:10.1021/ja411457r

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate (1292268-15-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ethanol / 0 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide / water; toluene / 1 h / 100 °C

3.2: 20 - 100 °C

4.1: triethylamine / dichloromethane / 0.08 h / 0 °C

4.2: 24 h / 0 - 20 °C

5.1: sodium azide; sodium iodide / water; acetone / 48 h / 80 °C

With dmap; sodium azide; triethylamine; sodium iodide; sodium hydroxide; In ethanol; dichloromethane; water; acetone; toluene;

DOI:10.1002/ejoc.201001666

upstream raw materials:

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate

t-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate

2,2-dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-yl 4-methylbenzenesulfonate

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1292268-15-5 t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send