129286-87-9

Upstream product

• 56826-69-8 5,6,7,8-tetrahydro-8-quinolinone 
• 25287-79-0 3-dimethylamino-1,2-diphenyl-propan-1-one hydrochloride 
• 5400-92-0 3-dimethylamino-2-methyl-1-phenyl-propan-1-one; hydrochloride 
• 451-40-1 phenyl benzyl ketone 
• 93-55-0 1-phenyl-propan-1-one 

Relevant academic research and scientific papers

Facile synthesis of polycyclic pyridines, bipyridines, and oligopyridines

The preparation of polycyclic heterocycles with one or more nitrogen atoms and different binding angles by a domino reaction is described, These compounds (4-6, 8a-b) are formed by the reaction of β-amino ketone hydrochlorides 1 or 2 (Mannich bases) with ketones 3. Especially the synthesis of the terpyridines 8a and 8b in a double domino reaction is very useful (yield 70 and 59%) and opens a route to torands. VCH Verlagsgesellschaft mbH, 1996.

β-Amino Ketones as Key Intermediates in the Synthesis of Pyridines: A Novel and Efficient Route to Annelated Bi- and Terpyridines

The hydrochlorides of β-amino ketones 1a-e (Mannich bases) are easily obtained starting compounds for a novel synthesis of pyridines.Condensation with the heteroaromatic ketones 8, 9, and 10 yields 5,6-dihydro-1,10-phenanthrolines 3a-d, 13 and 4,5-diazafluorenes 4a-d, which have not yet been described in literature.Symmetrical terpyridines 3e, 4e are formed in a one-step reaction of 8, 9 with dimethylmethylenammonium chloride in the presence of an ammonia source.